SESSION TYPE: Physiology/PFTs/ Rehabilitation II
PRESENTED ON: Monday, October 22, 2012 at 11:15 AM - 12:30 PM
PURPOSE: Even if we give antitussive treatment for the patients with prolonged and chronic cough, we recognize the case that cannot obtain enough antitussive effect. We investigated antitussive effect using soft extensible chest band for this kind of the case.
METHODS: We examined for a multicenter, an open-label, single-arm, phase 2 trial for one year from April, 2010. ( HARAOBI study )We evaluated an effect for the antitussive effect by soft extensible chest band for the case that cannot obtain enough effects by cough remedy in before and after therapy. Effect measurement target is the patients used soft extensible chest band more than eight hours a day.The primary outcome was the change of cough related VAS and LCQ (Leicester Cough Questionnaire ) in before and after therapy.The second end-point was antitussive reduction rate, treatment continuation rate, and adverse event. This trial has been completed and is registered with UMIN Clinical Trials Registry, number UMIN000003577.
RESULTS: 56 patients (male/female: 27/29) were enrolled. The median age is 63 years old. The causative disease of the cough was 34 interstitial pneumonia , 13 lung cancer, nine cases other disease.49 patients (88%) showed improvement in VAS.33 cases (59%) were able to reduce the antitussive.Additionally, 50 patients (89%) hoped for continuation of the antitussive treatment using soft extensible chest band.We checked one pneumothorax as complications after the treatment. However, tolerability of the treatment was good without severe adverse event.
CONCLUSIONS: The antitussive effect by soft extensible chest band gets good response, and we think that soft chest band therapy for intractable, prolonged and chronic cough is safety and effective therapy.
CLINICAL IMPLICATIONS: Persistent dry cough effectively may treat by soft extensible chest band.
DISCLOSURE: The following authors have nothing to disclose: Mitsuhiro Sumitani, Shigeki Nanjo, Natsuko Miyamoto, Shinya Yoshida, Manabu Tsuda, Masayoshi Nishijima, Seiichi Shoji, Keisuke Tomii, Nobuyuki Katakami, Koji Miyamoto
we experienced patient's cough symptom was relieved by breathing relaxation performed for dyspnea palliation. Based on this experience and we attached the extensible soft chest band to the patient for thoracic cage compression ,the patient got antitussive effect by this treatment. We thought the possibility that treatment with the extensible soft chest band could be good treatment for intractable non-productive cough.Department of Respiratory Medicine, Osaka City General Hospital, Osaka, Japan