SESSION TYPE: Respiratory Infections Posters II
PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM
PURPOSE: To assess the effect of combined fluticasone and salmeterol(FPS) on RSV infection in Fischer344 rats
METHODS: RSV-infected rats were treated intranasally with combined fluticasone and salmeterol either before or after RSV infection. Then, we examined airway hyperreactivity(AHR), RSV titier, lung histology and level of cytokines.
RESULTS: FPS did not reduce AHR, RSV titer and lung inflammation on histology sections in RSV infected rats. Also FPS did not reduce cytokine production in RSV infected rats.
CONCLUSIONS: Combined fluticasone and salmeterol(FPS) has little effect on RSV infection in rats.
CLINICAL IMPLICATIONS: Combined steroid inhaler would not be useful in treatment of RSV infection.
DISCLOSURE: The following authors have nothing to disclose: Sang-Joon Park, Shyam Mohapatra, Richard Lockey
No Product/Research Disclosure InformationMyongji Hospital, Kwandong University College of Medicine, Goyang-si, Republic of Korea