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Chest Infections |

The Effect of the Combined Fluticasone and Salmeterol on Respiratory Syncytial Virus (RSV) Infection in Rats

Sang-Joon Park*, MD; Shyam Mohapatra, PhD; Richard Lockey, MD
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Myongji Hospital, Kwandong University College of Medicine, Goyang-si, Republic of Korea


Chest. 2012;142(4_MeetingAbstracts):226A. doi:10.1378/chest.1388111
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Abstract

SESSION TYPE: Respiratory Infections Posters II

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: To assess the effect of combined fluticasone and salmeterol(FPS) on RSV infection in Fischer344 rats

METHODS: RSV-infected rats were treated intranasally with combined fluticasone and salmeterol either before or after RSV infection. Then, we examined airway hyperreactivity(AHR), RSV titier, lung histology and level of cytokines.

RESULTS: FPS did not reduce AHR, RSV titer and lung inflammation on histology sections in RSV infected rats. Also FPS did not reduce cytokine production in RSV infected rats.

CONCLUSIONS: Combined fluticasone and salmeterol(FPS) has little effect on RSV infection in rats.

CLINICAL IMPLICATIONS: Combined steroid inhaler would not be useful in treatment of RSV infection.

DISCLOSURE: The following authors have nothing to disclose: Sang-Joon Park, Shyam Mohapatra, Richard Lockey

No Product/Research Disclosure Information

Myongji Hospital, Kwandong University College of Medicine, Goyang-si, Republic of Korea

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