Obstructive Lung Diseases |

CAT Scores May Reflect the Physiological Changes in COPD Patients FREE TO VIEW

Elif Sen*, MD; Fatma Arslan, MD; Gokcen Arkan, MD; Duygu Acar, MD; Pinar Onen, MD; Banu Gulbay, MD; Oznur Yildiz, MD; Turan Acican, MD; Sevgi Saryal, MD; Gulseren Karabiyikoglu, MD
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Ankara University Medical Faculty, Ankara, Turkey

Chest. 2012;142(4_MeetingAbstracts):674A. doi:10.1378/chest.1387381
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PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: COPD assessment test(CAT) is a measurement tool for health status impairment composed of 8 question, score ranges from 0-40. In GOLD 2011 update, patients with CAT scores ≥ 10 are classified to be more symptomatic group. This study aimed to evaluate the relationship between CAT scores and clinical, physiologic parameters in COPD patients.

METHODS: 125 patients with COPD in stable conditions were included in the study. CAT scores, MRC scores, arterial blood gas measurements, spirometry, six minute walking test, body mass index and blood CRP levels were measured. Patients were divided in two groups according to CAT scores; Less symptomatic Group A (CAT score < 10) and more symptomatic Group B (CAT score ≥10). The comparisons were performed between these two groups.

RESULTS: 125 COPD patients (20 woman, 105 man) were studied. Mean values were 66,82 ±10,93 for age, 60,22 ±21,10 for FEV1 %, 60,57 ±12,12 FEV1/ FVC % and 14,77 ± 8,69 for CAT scores. Patients were divided in two groups according to CAT scores; Less symptomatic Group A (CAT score < 10) and more symptomatic Group B (CAT score ≥10).mMRC scores were higher (p<0,001), FVC % (p=0.001) and FEV1 % values(p=0,003) were significantly lower in group B. 6MWD was decreased in group B(p =0,03). In this high scoring group, lower mean PaO2 (p= 0,005), higher mean PaCO2 (p= 0,03),lower mean oxygen saturation values (p <0,001). were detected. Both groups showed any significant difference for BMI and CRP levels.

CONCLUSIONS: In conclusion, more symptomatic patients according to higher CAT scores had significant decrease in expiratory flow rates, exercise capacity and impairment in ABGs. The patophysiological changes were correlated with changes in health status of patients with COPD.

CLINICAL IMPLICATIONS: In COPD, health status is considered to be a determinant of the disease progression and prognosis. Spirometric measurement may be insufficient in the global evaluation of the patients. Other clinical evaluation tools as health status may be useful. In this study, we found a significant relationship between physiological measurements and health status. This result suggested that multidimensional and associative evaluation tools may be convenient in daily practice as proposed in GOLD 2011 update.

DISCLOSURE: The following authors have nothing to disclose: Elif Sen, Fatma Arslan, Gokcen Arkan, Duygu Acar, Pinar Onen, Banu Gulbay, Oznur Yildiz, Turan Acican, Sevgi Saryal, Gulseren Karabiyikoglu

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Ankara University Medical Faculty, Ankara, Turkey




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