Diffuse Lung Disease |

Airway Hyperresponsiveness in Patients With Bronchiectasis FREE TO VIEW

Jamsak Tscheikuna*, MD
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Mahidol University, Bangkok, Thailand

Chest. 2012;142(4_MeetingAbstracts):428A. doi:10.1378/chest.1387303
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SESSION TYPE: Cystic Fibrosis/ Bronchiectasis Posters

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: Bronchiectasis is a chronic lung disease and commonly found in the patients with chronic cough. This disease caused chronic pulmonary infection, impaired pulmonary function, and increased morbidity and mortality. Prevalences of airway hyperresponsiveness(AHR) in bronchiectatic patients are vary between studies. This study aims to determine the prevalence and predictors of airway hyperresponsiveness in patients with bronchiectasis.

METHODS: A cross-sectional study was performed to evaluate 33 bronchiectatic patients between May 2010 and December 2010. Demographic data including sex, age, smoking status, occupation, co-morbid diseases, underlying lung diseases, clinical features, radiographic findings, and treatments were analyzed. Methacholine challenge test(MCT), pulmonary function test and exhaled nitric oxide(NO) were measured.

RESULTS: The prevalence of AHR was 18% (6 of 33 patients). Their exhaled NO levels were all in normal limit. There was no correlation between MCT and exhaled NO level, also between airway responsiveness and demographic data predictors.

CONCLUSIONS: Prevalence of AHR in bronchiectatic patients was higher than general adult population. Mechanism of AHR in bronchietasis may be different from in asthma and no predictor was found in this study.

CLINICAL IMPLICATIONS: The use of bronchodilator may be benefit in some patients with bronchiectasis but the use of inhale steroid may not indicate.

DISCLOSURE: The following authors have nothing to disclose: Jamsak Tscheikuna

No Product/Research Disclosure Information

Mahidol University, Bangkok, Thailand




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