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Pulmonary Vascular Disease |

Prevalence and Predictors of Pulmonary Embolism in Korean Patients With Exacerbation of Chronic Obstructive Pulmonary Disease

Seung-Ick Cha*, MD
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Kyungpook National University Hospital, Daegu, Republic of Korea


Chest. 2012;142(4_MeetingAbstracts):834A. doi:10.1378/chest.1384975
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Abstract

SESSION TYPE: DVT/PE/Pulmonary Hypertension Posters II

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: The purpose of the present study was to investigate the prevalence and predictors of PE in Korean patients with COPD exacerbation.

METHODS: Hospitalized patients with COPD exacerbations were enrolled into this study prospectively and underwent computed tomography (CT) pulmonary angiography and indirect CT venography.

RESULTS: The most common cause of COPD exacerbation was lower respiratory tract infection (82% [n=84]), followed by PE (5% [n=5]). Eight patients (8%) had venous thromboembolism, and deep vein thrombosis (DVT) was seen in 6%, with proximal DVT in 4%. On multivariate analysis, the absence of symptoms of respiratory infection and plasma D-dimer elevation (≥500 μg/l) were significant factors predicting PE in patients with COPD exacerbations (Odds ratio [OR] 31, 95% confidence interval [CI] 2-563, p=0.02; and OR 25, 95% CI 1-464, p=0.03, respectively).

CONCLUSIONS: PE comprises approximately 5% of the etiologies of COPD exacerbations in Koreans. The absence of symptoms suggestive of respiratory infection and elevated plasma D-dimer level were significant predictors of PE in this population.

CLINICAL IMPLICATIONS: Although PE is an uncommon cause of COPD exacerbation in Koreans, it should be considered one of the causes in the patients with the absence of symptoms of respiratory infection or plasma D-dimer elevation.

DISCLOSURE: The following authors have nothing to disclose: Seung-Ick Cha

No Product/Research Disclosure Information

Kyungpook National University Hospital, Daegu, Republic of Korea

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