SESSION TYPE: Sepsis/Shock
PRESENTED ON: Sunday, October 21, 2012 at 10:30 AM - 11:45 AM
PURPOSE: Effect of improved compliance to 6-hour sepsis resuscitation bundle and mortality reduction in severe sepsis and septic shock patients.
METHODS: Quasi-experimental prospective study conducted at 10- bedded combined medical and surgical ICU. The historical group included all consecutive patients with severe sepsis and septic shock admitted from January 2008 to March 2009. Intervention included evidence based written sepsis pathway, antibiotic recommendations and educational program. Post-intervention group included all consecutive patients admitted from July 2009 to June 2011. The primary outcome measures were the overall compliance to seven 6-hour sepsis resuscitation bundle elements and 30-day hospital mortality
RESULTS: There were 99 patients in historical group and 199 in post-intervention group. The baseline patients’ characteristics were similar. Overall compliance to all seven sepsis resuscitation bundle elements in historical group was 5.1% (95% CI, 2.1% - 11.3%) which improved after intervention to 23.6% (95% CI, 17.9% - 30.1 %); p < 0.001. Also, overall compliance was related to improved survival [OR 5.8 (95% CI, 2.2 - 15.1; p < 0.001)]. 30-day hospital mortality reduced from 31.3% to 21.1%; p = 0.05.
CONCLUSIONS: Our intervention significantly improved compliance to 6-hour sepsis resuscitation bundle and reduction in 30-day hospital mortality.
CLINICAL IMPLICATIONS: All efforts should be made to comply and improve 6-hour sepsis resuscitation bundle in patients with severe sepsis and septic shock to decrease the mortality.
DISCLOSURE: The following authors have nothing to disclose: Javed Memon, Rifat Rehmani, Abdulsalam Alaithan, Ayman Al-Gammal, Talib Lone, Khaled Ghorab, Abdulsaboor Basirat
No Product/Research Disclosure InformationKing Abdulaziz National Guard Hospital, Al Ahsa, Saudi Arabia