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Cardiothoracic Surgery |

Assessment of Health Related Quality of Life After Video-Assisted Thoracoscopic Lobectomy for Early Stage Lung Cancer

Sayf Gazala*, MBChB; Jeffery Johnson, PhD; Jim Kutsogiannis, MD; Eric Bedard, MD
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University of Alberta, Edmonton, AB, Canada


Chest. 2012;142(4_MeetingAbstracts):57A. doi:10.1378/chest.1384599
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Abstract

SESSION TYPE: Thoracic Surgery Posters I

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: To assess the HRQL in patients with early stage NSCLC undergoing Video Assisted Thoracoscopic (VATS) lobectomy.

METHODS: We performed a prospective study of NSCLC patients undergoing VATS lobectomy at our tertiary care, teaching center. Before surgery, baseline assessment of HRQL was captured using the SF-36, the EORTC QLQ30 and QLQ13 and the EQ-5D questionnaires. Post-operative assessment of HRQL was conducted at regular intervals (2, 4, 8 and 12 weeks) after surgery, using the same questionnaires administered at baseline. Changes in HRQL scores over the follow-up period were compared using paired t-test.

RESULTS: Between March and September 2011, 44 eligible patients were recruited into the study. The mean age was 65.1 (SD 8.7; range: 46-81) years; 24 (55%) were male. Tumor stage was IA in 55%, IB in 30%, IIA in 7%, IIB in 7% and IIIA in 2%. The median chest tube duration was 3 (mean 5, SD 3.9) days. The median length of stay was 5 (mean 6.1, SD 4.7) days. Three patients had conversion to thoracotomy and remained in the study. Two months after surgery, patients were still below their baseline HRQL measured by the EORTC QLQ 30 and QLQ13 in the following scales and symptoms: Global Health Status, Role Limitation - Physical, Dyspnea, Fatigue, Chest Pain and Shoulder Pain (p<0.05 for all). By three months after VATS lobectomy, patients experienced return to their baseline HRQL in 6 of 8 domains of the SF-36: Global Health, Bodily Pain, Physical Functioning, Social Functioning, Mental Health and Role Limitations - Emotional (p>0.05 for all). The EQ-5D questionnaire showed no significant difference.

CONCLUSIONS: While previous work have shown that HRQL after thoracotomy for lung cancer resection impairs patients’ HRQL for a period of six to twelve months, those undergoing VATS lobectomy regain most of their baseline HRQL in as soon as three months post operatively.

CLINICAL IMPLICATIONS: VATS lobectomy has a better impact on patients' HRQL, with most of the patients return to their baseline HRQL within 3 months after surgery, regardless of their length of stay and post-operatie complication.

DISCLOSURE: Sayf Gazala: Grant monies (from industry related sources): Johnson and Johnson research operational grant

Jeffery Johnson: Grant monies (from industry related sources): Johnson and Johnson research operational grant

Jim Kutsogiannis: Grant monies (from industry related sources): Johnson and Johnson research operational grant

Eric Bedard: Grant monies (from industry related sources): johnson and Johnson research operational grant

No Product/Research Disclosure Information

University of Alberta, Edmonton, AB, Canada

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