SESSION TYPE: Pneumonia Morbidity and Mortality
PRESENTED ON: Sunday, October 21, 2012 at 01:15 PM - 02:45 PM
PURPOSE: Antimicrobial therapy has been the main stay of therapy of community-acquired aspiration pneumonia (CAAP) but the duration of treatment has not been established. The objective of this study was to describe the time to reach clinical stability in patients with aspiration pneumonia compared to community-acquired pneumonia (CAP).
METHODS: A retrospective case control study at two university affiliated centers encompassing 329 consecutive patients admitted with CAAP and 329 consecutive patients with CAP was conducted between 2007 and 2011.
RESULTS: While the median time to stability for patients with CAP was distributed around a median of 4 days, there was a bimodal distribution for time to clinical stability in patients with CAAP with dual peaks at days 2 and 5, respectively. CAAP patients who required more than 2 days to achieve clinical stability had higher mortality rate compared to those with 2 days or less (OR 5.95, 95% CI 2.85 to 12.4) and longer hospital stay (6.6±5.8 vs. 3.9±1.2 days; p<0.001). None of the CAAP patients who achieved clinical stability in 2 days or less was transferred to a higher level of care. In a multivariate analysis, time to clinical stability was found to be independent predictor of outcome in patients with CAAP (OR 2.59; 95% CI 2.02-3.32).
CONCLUSIONS: Normalization of vital signs in aspiration pneumonia follows a distinct pattern from patients with CAP. Time to achieve clinical stability may assist in identifying CAAP patients who are likely to require shorter hospital stay and lesser exposure to antimicrobial therapy
CLINICAL IMPLICATIONS: If our data is confirmed by multicenter, prospective studies, use of antimicrobial therapy in aspiration syndromes may be guided by time to clinical stability.
DISCLOSURE: The following authors have nothing to disclose: Philippe Jaoude, Anil Anandam, Ali El Solh
No Product/Research Disclosure InformationSUNY at Buffalo, Buffalo, NY