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Lung Cancer |

Bronchogenic Carcinoma at a University Hospital in Egypt: A Case Control Study

Eman Mohammad, MD; Mohammad ElHofy, PhD; Mahmoud Mahmoud, PhD; Mohamed Samy Atta*, PhD; Ali Hasab, PhD
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University of Alexandria, Faculty of Medicine, Chest Diseases Department, Alexandria, Egypt


Chest. 2012;142(4_MeetingAbstracts):644A. doi:10.1378/chest.1378259
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Abstract

SESSION TYPE: Lung Cancer Posters II

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: Lung cancer problem in Egypt is not yet well estimated. The present study was conducted to identify some features of bronchogenic carcinoma regarding risk factors, clinical presentations, radiological findings, diagnostic procedures, histopathological types and clinical staging.

METHODS: A total of 212 patients (101 cases and 111 controls) were studied at Alexandria Main University Hospital (MUH). The cases were included when lung cancer diagnosis was confirmed by tissue diagnosis. The controls were patients who had no lung disease or cancer lesion at the time of the study. Both cases and controls were subjected to a predesigned questionnaire, while the cases were subjected to clinical, radiological examination, tissue biopsy and clinical staging.

RESULTS: Smoking was the most important risk factor as ever smoker carried more than 7 times risk. Duration of smoking was more risky than number of packs smoked per day. Males, elderly people and urban residents had about 3 times increased risk. Exertional dyspnea was the commonest manifestation. Bronchoscopy was the commonest procedure performed to diagnose central tumor while transthoracic needle biopsy diagnosed most of peripheral tumors. Pleural effusion was present in one third of the cases but malignant pleural effusion was confirmed in 72% of them. Thoracoscopy was used to diagnose some of the cases with malignant pleural effusion secondary to lung cancer. Large cell carcinoma was the commonest histopathological type followed by squamous cell carcinoma.Long duration of smoking was the commonest factor related to the late presentation of most of the cases.

CONCLUSIONS: Features of bronchogenic carcinoma in our study population are similar to those present worldwide regarding risk factors, clinical and radiological presentation. However we have found a unique distribution of histopathological types. There is a delay in presentation and management of most of our cases.

CLINICAL IMPLICATIONS: Unusual incidence of large cell carcinoma deserves further investigations. The burden of environmental pollutants especially industrial one has to be well studied. Health education and multidisciplinary teamwork are essential for better management of lung cancer.

DISCLOSURE: The following authors have nothing to disclose: Eman Mohammad, Mohammad ElHofy, Mahmoud Mahmoud, Mohamed Samy Atta, Ali Hasab

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University of Alexandria, Faculty of Medicine, Chest Diseases Department, Alexandria, Egypt

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