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Obstructive Lung Diseases |

The Relationship of Pulmonary Hypertension (PH) and Severe COPD

Perlat Kapisyzi*, PhD; Dhimitraq Argjiri, MD; Loreta Bica, MD; Jola Klosi, MD; Anila Aliko, PhD; Jeta Beli, PhD; Ylli Vakeffliu, MD; Roland Kore, MD; Elenka Shehu, PhD; Ornela Nuredini, MD; Mirela Tabaku, PhD; Epaminonda Fype, MD
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Faculty of Medicine, Tirana, Albania


Chest. 2012;142(4_MeetingAbstracts):714A. doi:10.1378/chest.1367800
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Abstract

SESSION TYPE: COPD Posters I

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: The aim of the study was to evaluate the correlation between gravity of COPD and PH as a complication.

METHODS: A total of 44 hospitalised patients enrolled in the study. The diagnose of PH was made using standard clinical, echorgaphic and thoracic CT. The classification of COPD was made according GOLD

RESULTS: Mean age of patients enrolled in study was 70.4 ± 7.96, smokers were 35 (79%) patients. Thirty eight (87.4%) patinets had FEV1 < 50%; of them 20 (52.3%) patients in stage IV and 18 (47.7%) in stage III. 6 (13.6%) patients had PSAP under 34 mmHg, 16 (36.36%) had PSAP of 35-44 mmHg and 22 (50%) patients had PSAP >45 mmHg. Patients with FEV1>50% of predicted had e PH level of 30.6±3.8 mmHg, comparing 42.36±9.7mmHg in patients with FEV1 < 50% of predicted (p=0.0156). No significant difference is shown between hypoxemic patients (PaO2<60 mmHg;) and normoxemic patients according PH level. Patients with PH < 44 mmHg 22 (50 %) had a tapse of 18.5±1.4, comparing 13.5±1.14 in patients with PH >45 mmHg 22(50%), (p=0.0001). Significant difference is seeing also according left cardic function (EF) and gravity of PH. Thirteen (29.5%) patients with EF < 0.6, had PH level of 47.3±14mmHg, comparing 36.6±7.9mmHg in patients with EF > 0.6, (p=0.0358)

CONCLUSIONS: The increase in pulmonary artery pressures is often mild to moderate, but in severe COPD, patients may suffer from severe pulmonary hypertension with or without resting PH.

CLINICAL IMPLICATIONS: The correlation of severity of spirometric findings with heart echorgaphic ones.

DISCLOSURE: The following authors have nothing to disclose: Perlat Kapisyzi, Dhimitraq Argjiri, Loreta Bica, Jola Klosi, Anila Aliko, Jeta Beli, Ylli Vakeffliu, Roland Kore, Elenka Shehu, Ornela Nuredini, Mirela Tabaku, Epaminonda Fype

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Faculty of Medicine, Tirana, Albania

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