SESSION TYPE: Respiratory Infections Posters II
PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM
PURPOSE: The aim of the study was to eveluate benefical effect of corticosterides in short treatment of community aquired pneumonia (CAP).
METHODS: We enrolled a total of 149 hospitalized patients, for a period of an year (Januay 2011 to Decembre 2011). The diagnose of CAP was made using standard clinical and radiological criteria. Disease severity was scored using Pneumonia Severity Index. Age , antibiotic treatment and PSI adjustement has been done between the groups. Patients received 50 mg prednisolone for 7 days, along with antibiotics. The outcomes were clinical cure at day seven, defervescence, length of stay, time to clinical stability,
RESULTS: Mean age of patients enrolled in study was 63±16.7 in prednisolone and 53±18.6 in group without prednisolone [p=0.0007]. Therty (40 %) patients in prednisolone group and 16(22.2%) in without prednisolone group were in Peumonia Severity Index class IV-V. Clinical cure at days 7 was 58/75 (80.3%) in the prednisolone group and 44/72 (61.1%) in other group.[P < 0.05). Patients on prednisolone had faster defervescence compared with other group, (p<0.0032). Length of stay was significally lower in patients with prednisolone compared with nonprednisolone group, 9.4±4.33 and 12.3±6.4 respectively, (p=0.0011). Adverse events were few and not different between the two groups.
CONCLUSIONS: In this study we show that Prednisolone (at 50 mg) once daily for a short time, (a week), have a beneficial effects in patients hospitalized with mild to severe CAP, improving outcomes without adverse events.
CLINICAL IMPLICATIONS: Treatment of mild, severe pneumonia with corticosteroide
DISCLOSURE: The following authors have nothing to disclose: Perlat Kapisyzi, Dhimitraq Argjiri, Anila Aliko, Jeta Beli, Ylli Vakeffliu, Roland Kore, Elenka Shehu, Ornela Nuredini, Regina Hasa, Loreta Bica, Mirela Tabaku, Epaminonda Fype
No Product/Research Disclosure InformationFaculty of Medicine, Tirana, Albania