Chest Infections |

Relation Between Clinical Pulmonary Infection Score, C-Reactive Protein, and Procalcitonin and Mortality in Patients With Hospital Acquired Pneumonia FREE TO VIEW

Yavuz Havlucu, MD; Aysin Coskun, MD; Seher Cam, MD; Nazmiye Gonen, MD; Tugba Goktalay, MD; Pinar Celik, PhD; Arzu Yorgancioglu*, PhD
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Celal Bayar University Medical Faculty, Manisa, Turkey

Chest. 2012;142(4_MeetingAbstracts):224A. doi:10.1378/chest.1364855
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SESSION TYPE: Respiratory Infections Posters II

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: Early diagnosis and treatment affect mortality in hospital-acquired pneumonia (HAP).Therefore, clinicians need some objective parameters for guiding treatment. The aim of this study was to determine the course of ‘‘clinical pulmonary infection score’’(CPIS),C-reactive protein(CRP) and procalcitonin (PCT) in patients under treatment as well as the relationship of these parameters with each other and mortality.

METHODS: Patients diagnosed followed as HAP were evaluated retrospectively. PIS, CRP and PCT assays were assessed on the beginning and follow up. One month mortality rate of all were recorded.

RESULTS: Among the 74 patients, there were 46 males (62,2%) and mean age was 65,6±15,8 years. The mean duration for HAP development was 7,4±5,6 days. 22 patients (29,7%) were died in a one month. We demonstrated a significant change between the first and the follow-up values of fever (p<0,001),leukocyte (p<0.001),PaO2/FiO2 (p=0.023), secretion presence (p<0.001), CRP (p=0,031), as well as total CPIS (p=0.007). However, there wasn’t a significant difference in PCT levels. There was correlation between total CPIS and CRP (p=0,008, r=0,308) and duration of hospitalization (p=0,046, r=0,232). Total CPIS value (p=0,021) and leukocyte number as domain of CPIS parameters (p=0,015) were related with one month mortality. Other CPIS parameters, CRP, PCT, and duration for HAP development were not related with one month mortality.

CONCLUSIONS: As a result, CRP and PCT were related with mortality but CPIS including clinical parameters and tests that are more cheaper and used widespreadly was related with mortality.

CLINICAL IMPLICATIONS: CPIS can be used to detect mortality in patients with HAP.

DISCLOSURE: The following authors have nothing to disclose: Yavuz Havlucu, Aysin Coskun, Seher Cam, Nazmiye Gonen, Tugba Goktalay, Pinar Celik, Arzu Yorgancioglu

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Celal Bayar University Medical Faculty, Manisa, Turkey




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