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Postgraduate Education Corner: Contemporary Reviews in Sleep Medicine |

Treatment of Complex Sleep Apnea SyndromeComplex Sleep Apnea Syndrome

Tomasz J. Kuźniar, MD; Timothy I. Morgenthaler, MD, FCCP
Author and Funding Information

From the Department of Internal Medicine (Dr Kuźniar), 4th Clinical Military Hospital, Wrocław, Poland; and Division of Pulmonary and Critical Care (Dr Morgenthaler), Mayo Clinic, Rochester, MN.

Correspondence to: Timothy I. Morgenthaler, MD, Division of Pulmonary and Critical Care Medicine, 200 First St SW, Rochester, MN 55905; e-mail: tmorgenthaler@mayo.edu


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2012;142(4):1049-1057. doi:10.1378/chest.11-3223
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Complex sleep apnea syndrome (CompSAS) describes the coexistence or appearance and persistence of central apneas or hypopneas in patients with obstructive sleep apnea upon successful restoration of airway patency. We review data on treatment of CompSAS with CPAP, bilevel positive airway pressure, and adaptive servoventilation and discuss evidence for the addition of medications (analgesics, hypnotics, acetazolamide) and gases (oxygen, CO2) to positive airway pressure therapy. Future research should focus on defining outcomes in patients with CompSAS and allow for more accurate tailoring of therapy to the pathophysiology present in the individual patient.

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