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IgG4-Related Systemic Disease Presenting With Lung Entrapment and Constrictive PericarditisIgG4-Related Systemic Disease

Hiroshi Sekiguchi, MD; Ryohei Horie, MD; James P. Utz, MD; Jay H. Ryu, MD
Author and Funding Information

From the Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.

Correspondence to: Hiroshi Sekiguchi, MD, Division of Pulmonary and Critical Care medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905; e-mail: sekiguchi.hiroshi@mayo.edu


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2012;142(3):781-783. doi:10.1378/chest.11-2608
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We describe a 29-year-old woman who presented with chronic pleuropericarditis complicated by lung entrapment and constrictive pericarditis. Pleural biopsy performed during the decortication procedure revealed fibrinous pleuritis with lymphoplasmacytic inflammation including IgG4-positive plasma cells. The patient responded favorably to corticosteroid therapy with resolution of pleural effusion and constrictive physiology. To our knowledge, this is the first reported case of IgG4-related systemic disease manifesting as lung entrapment and constrictive pericarditis.

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