0
Editorials |

Scleroderma Lung-Associated CoughScleroderma Lung-Associated Cough: More Than Meets the Eye?

Kaiser G. Lim, MD, FCCP
Author and Funding Information

From the Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic Rochester.

Correspondence to: Kaiser G. Lim, MD, FCCP, Mayo Clinic Rochester, Gonda 18-478, 200 First St SW, Rochester, MN 55905; e-mail: lim.kaiser@mayo.edu


Financial/nonfinancial disclosures: The author has reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2012;142(3):556-557. doi:10.1378/chest.12-0170
Text Size: A A A
Published online

Extract

In this issue of CHEST (see page 614), Theodore et al1 examined whether cough is related to disease activity and its response to immunosuppressive therapy. Most of the subjects in the study had dry, intermittent, mild to moderate cough. Only 5% (n =6) reported severe persistent cough, and only 9% had productive cough. They found that only cough frequency, but not severity or phlegm production, correlated with lower physical quality of life, more dyspnea, and lower diffusing capacity of the lung for carbon monoxide. Subjects who reported cough as a symptom had more fibrosis (higher lung and skin fibrosis scores) when compared with subjects without cough. After 1 year of treatment with cyclophosphamide, the percentage of subjects reporting cough decreased over the 6- to 18-month time period. The improvement was not sustained and was gone by 24 months. Based on these findings, the authors suggest that cough may be a surrogate measure of ongoing fibrosis and alveolar inflammation.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543