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The Homogeneous and Robust Clinical Phenotype of Severe Lung InjuryClinical Phenotype of Severe Lung Injury

Margaret S. Herridge, MD, MPH; for the REVA Study Group
Author and Funding Information

From the University of Toronto, University Health Network.

Correspondence to: Margaret S. Herridge, MD, MPH, University of Toronto, University Health Network, 11NCSB-1180, 585 University Ave, Toronto, ON, M5G 2C4, Canada; e-mail: margaret.herridge@uhn.on.ca


Financial/nonfinancial disclosures: The author has reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2012;142(3):553-556. doi:10.1378/chest.12-1204
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Acute-onset severe lung injury, regardless of etiology or associated risk factors, is universally recognized in terms of its sameness. Patients with this condition share many similarities, including younger age, few comorbidities, recovery of lung function in those without preexisting lung disease, ICU-acquired weakness (ICUAW), and neuropsychologic dysfunction. These patients also share resilience and recovery from a profound, multisystem, and exuberant inflammatory response. These outcomes are robust over time and across different countries and investigators.

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