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Omalizumab as a Steroid-Sparing Agent in Chronic Eosinophilic PneumoniaEosinophilic Pneumonia Treated with Omalizumab

Hatice Kaya, MD; Seyfettin Gümüş, MD; Ergun Uçar, MD; Mehmet Aydoğan, MD; Uğur Muşabak, MD; Ergun Tozkoparan, MD; Hayati Bilgiç, MD
Author and Funding Information

From the Turkish Armed Forces Rehabilitation Center (Dr Kaya); the Department of Pulmonary Medicine (Drs Gümüş, Uçar, Aydoğan, Tozkoparan, and Bilgiç); and the Department of Allergy and Clinical Immunology (Dr Muşabak), Gulhane Military Medical Academy, Ankara, Turkey.

Correspondence to: Hatice Kaya, MD, TSK Rehabilitasyon Merkezi, 06540, Bilkent, Ankara, Turkey; e-mail: drhaticekaya@yahoo.com


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2012;142(2):513-516. doi:10.1378/chest.11-1881
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Chronic eosinophilic pneumonia (CEP) is an idiopathic eosinophilic pulmonary disease characterized by an abnormal and marked accumulation of eosinophils in the lung. Common presenting complaints include cough, fever, dyspnea, wheezing, and night sweats. Common laboratory abnormalities are peripheral blood and BAL eosinophilia. The pathognomonic radiographic finding is bilateral peripheral infiltrates. Corticosteroids are the mainstay of therapy, and dramatic improvement follows treatment. Relapses are common, and most patients require prolonged therapy. Side effects associated with chronic corticosteroid therapy must be monitored. Our case was that of a 36-year-old woman who had characteristic clinical and radiologic features. She was treated with corticosteroids but she needed prolonged therapy, and side effects occurred. Because the patient had high IgE levels and a positive skin prick test result, we used omalizumab for the treatment. The patient responded well. To our knowledge, this is the first CEP case in the literature successfully treated with omalizumab.

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