0
Original Research: Disorders of the Pleura |

High Risk of Malignant Mesothelioma and Pleural Plaques in Subjects Born Close to OphiolitesOphiolites and Mesothelioma

Mehmet Bayram, MD; Isa Dongel, MD; Nur Dilek Bakan, MD; Hüseyin Yalçın, PhD; Ruhiye Cevit, MD; Pascal Dumortier, PhD; Benoit Nemery, MD, PhD
Author and Funding Information

From the Department of Pulmonology (Dr Bayram), the Department of Thoracic Surgery (Dr Dongel), and the Department of Pathology (Dr Cevit), Sivas Numune Hospital, Sivas, Turkey; the Department of Geological Engineering (Dr Yalçın), Cumhuriyet University, Sivas, Turkey; the Department of Pulmonology (Dr Bakan), Yedikule Teaching Hospital for Pulmonology and Thoracic Surgery, Istanbul, Turkey; the Chest Department (Dr Dumortier), Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium; and Occupational and Environmental Medicine (Dr Nemery), Unit of Lung Toxicology, Katholieke Universiteit Leuven, Leuven, Belgium.

Correspondence to: Mehmet Bayram, MD, Bezmialem Vakif University, Department of Pulmonology, Aksaray mah. Vatan cad. 34095 Fatih – Istanbul, Turkey; e-mail: drmehmetbayram@yahoo.com


Funding/Support: The authors have reported to CHEST that no funding was received for this study.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2013;143(1):164-171. doi:10.1378/chest.11-2727
Text Size: A A A
Published online

Background:  Ophiolites, a special sequence of geologic rock units, are known sources of naturally occurring asbestos. The aim of this study was to test whether the occurrence of malignant mesothelioma (MM) or pleural plaques (PPs) in the province of Sivas, Turkey, is determined by the proximity of the patient’s birthplace to ophiolites and, if so, to establish the magnitude of the risk.

Methods:  The birthplaces of patients with MM or PPs (cases) and patients with prostate or breast cancer (control subjects), diagnosed between 2000 and 2010 and identified through a mandatory cancer registry or from hospital records (PPs), were located on a geologic map, and the nearest distance to ophiolites was measured. The relation of MM or PPs with distance to ophiolites was analyzed by logistic regression. Samples of soil and house plaster were determined by x-ray diffraction.

Results:  Patients with MM (n = 100) or PPs (n = 133) were born significantly nearer to ophiolites (median distance, 4.5 km for men, 0 km for women) than were patients with prostate cancer (n = 161) or breast cancer (n = 139) (median distance, 20 km for both). ORs were 1.6 (men) (P < .001) and 2.0 (women) (P < .001) for every 5-km decrease in the distance of birthplace to ophiolites for MM, compared with prostate and breast cancer, respectively.

Conclusion:  In this area without substantial industrial asbestos use, there is an association between the occurrence of mesothelioma (and of PPs) and the proximity of the subject’s birthplace to ophiolites.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
Malignant Mesothelioma due to Environmental Exposure to Asbestos*: Follow-Up of a Turkish Cohort Living in a Rural Area
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543