PURPOSE: To assess the drug resistance pattern in chronic cases of tuberculosis.
METHODS: Chronic cases who attended the department of Pulmonary Medicine from December 2004 to December 2005 were interviewed on a predesigned proforma to know the socio-demographic profile and their culture & sensitivity pattern of sputum for mycobacterium tuberculosis.
RESULTS: Out of 48 cases, 34 cases were interviewed and 14 cases did not give consent for interview. Out of 34 cases, Culture /sensitivity was available for 31 cases. 30(97%) cases were resistant to one or more than one primary anti-tubercular drugs. 14(45.2%) cases had Multi-drug resistant tuberculosis (MDR-TB). Prevalence of MDR-TB was statistically significant and higher in joint families, rural areas and in patients with long duration of illness (> 4 years). Prevalence of MDR-TB was low in patients who received Directly Observed Treatment Shortcourse (DOTS)(33.3%)in comparison to other than DOTS (50.0%) .
CONCLUSION: Among chronic cases (Category IV) of tuberculosis, MDR-TB was found in 45.2% only.
CLINICAL IMPLICATIONS: Adequate supervised treatment under RNTCP is most effective way to prevent the emergence of chronic cases.
DISCLOSURE: Rajendra Prasad, None.