PURPOSE: High dose chemotherapy followed by autologus stem cells transplantation is an effective treatment for some malignancies resistant to conventional therapy or in advanced stage. However, poststansplant immunological reconstitution often required a long period of time which characterized with high susceptibility of patients to infections. In our study we estimated pulmonary tuberculosis incidence after stem cells transplantation.
METHODS: 119 long term survivors (Hodgkin’s disease, n=78; breast cancer, n=41) after high dose chemotherapy with autologus stem cells transplantation were followed up for the period of 26 (12 –36) months. None of the patients had any previous history of tuberculosis.
RESULTS: Five patients developed pulmonary tuberculosis during the follow up period. In four of them tuberculosis was diagnosed within first 12 months, giving an incidence rate of 3.4/100 person-year.
CONCLUSION: The results of our study provide the information regarding the high risk of pulmonary tuberculosis development in patients after high dose chemotherapy followed by autologus stem cells transplantation during first 12 months.
CLINICAL IMPLICATIONS: An introduction of special monitoring and preventive measures for this group of patients should be considered.
DISCLOSURE: Alena Skrahina, None.