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Abstract: Poster Presentations |

THE CORRECTION OF IMBALANCE IN OXYDANT-ANTIOXIDANT AND PROTEASE-ANTIPROTEASE SYSTEMS BY EFFERENT DETOXICATION METHODS IN COMMUNITY-ACQUIRED PNEUMONIA FREE TO VIEW

Alexander E. Makarevich, DO, PhD*; Julia J. Pancratova, DO; Valerij V. Kirkovsky, DO, PhD
Author and Funding Information

Belarusisan State Medical University, Minsk, Belarus



Chest. 2006;130(4_MeetingAbstracts):280S. doi:10.1378/chest.130.4_MeetingAbstracts.280S-b
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Abstract

PURPOSE: To assess influence of efferent detoxication methods (EDM) on these systems in blood pre-post severe community-acquired pneumonia (SCAP)treatment.

METHODS: 107 SCAP in-pts were divided into 4 comparable groups. Pts of the 1-st group underwent standard treatment with antibiotics (STA).Pts of the 2-nd-3-4-th groups were treated with additional courses of extracorporeal ultraviolet light-exposure (UVLE), biospecific hemosoptions (BSS) and BSS+UVLE respectively.

RESULTS: The baseline levels of malondialdehyde and syperoxidedysmutase activity were elevated by about 30% and 1,7 times in all groups (p<0,05 vs. the control). After using of EDM malondialdehyde level αwas decreased by 17%; 33%; 30% (p<0,05) in the 2-4-th groups, but didn’t differ in the 1-st group. Syperoxidedysmutase activity decreased after STA by 1,3 times and by 1,6 times in 2-4-th groups. Catalasa activity before treatment was decrease by 10% in the all groups (p<0,05 vs. the control). After therapy catalasa activity had even decreased by 16% in the 1-st group, didn’t change in the 2-nd group and increased by 6% and 13% (p<0,05) in the 3-4-th groups (achieving the norm). The baseline elastase level and trypsin activity were increased by about 5 times in the 1-4-th groups. After therapy elastase as well as trypsin activity were decreased by 1,5; 2,1; 4,1; 6,6 times (p<0,05) and by 2,1; 3,8; 6,4; 6,0 times (p<0,05) respectively. α1-antitrypsin level before treatment was decreased by about 2,8 times (p<0,05 vs. the control) in 1-st-4-th groups and significantly increased by 1,8; 2,2; 3,0; 2,7 times in these groups after therapy. The baseline level of α2-macroglobulin was significantly decreased by about 2 times in all groups and increased up to the norm to the end of treatment.

CONCLUSION: The use of EDM (better BSS+UVLE) in SCAP therapy is more effective vs. STA for faster improvement of imbalance in oxydant-antioxidant and protease-antiprotease systems.

CLINICAL IMPLICATIONS: The normalization of these systems was accompanied with faster reduction of the patient’s symptoms and roentgenologic terms resolution of SCAP by 3-4 days vs. STA.

DISCLOSURE: Alexander Makarevich, None.

Wednesday, October 25, 2006

12:30 PM - 2:00 PM


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