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Abstract: Poster Presentations |

EFFECT OF LUPUS RECIPE ON GENE EXPRESSION OF CD134, CD134L, AND RANTES FROM LUNG TISSUE OF LUPUS-PRONE BXSB MICE FREE TO VIEW

Yan-bin Zhou, MD, PhD*; Ren-gao Ye, MD; You-ji Li, MD; Can-mao Xie, MD, PhD; Bin Hu, MD; Yubiao Guo, MD, PhD
Author and Funding Information

First Affiliated Hospital of Sun Yat Set University Department of Pulmonary & CC, Guangzhou, Peoples Rep of China



Chest. 2006;130(4_MeetingAbstracts):279S. doi:10.1378/chest.130.4_MeetingAbstracts.279S-a
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Abstract

PURPOSE: To investigate the Effect of lupus recipe on gene expression of CD134, CD134L and RANTES from lung tissues of lupus –prone BXSB mice.

METHODS: Eighteen male lupus-prone BXSB model mice were divided into three groups: un-treated group; lupus recipe (LR) treated group; prednisone treated group. Meanwhile, 6 syngeneic normal C57BL/6 male non-lupus-prone mice were used as the control group. All model mice were killed in 10 weeks. RT-FQ-PCR was used to detect the mRNA expression of CD134, CD134L and RANTES in lung tissues.

RESULTS: (1) The mRNA expressions of CD134, CD134L and RANTES from lung tissues in un-treated group were obviously higher than those from control groups (p<0.05). The LR or prednisone significantly reduced the CD134, CD134L and RANTES mRNA expressions in LR treated group or prednisone treated group comparing with model group (p<0.05), while the difference between the treated group and the normal group was not significant. (2) There was a positive correlation between CD134L mRNA expression and RANTES mRNA expression in model lung tissues (r =0.793, P<0.05).

CONCLUSION: The abnormal expression of CD134, CD134L mRNA was well evidenced in the lung of lupus-prone BXSB mice.

CLINICAL IMPLICATIONS: Strong expression of RANTES mRNA was likely mediated by the activation of CD134/CD134L signal pathway. LR and corticosteroids could obviously inhibit the mRNA expressions of CD134, CD134L and RANTES.

DISCLOSURE: Yan-bin Zhou, None.

Wednesday, October 25, 2006

12:30 PM - 2:00 PM


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