PURPOSE: The aim of our investigation is to compare the effect of different antihypertensive drugs on lung function in hypertensive patients with and without clinical signs of left heart failure.
METHODS: This study was done on 80 patients with essential arterial hypertension.All patients had roent genographic and electrocardiographic signs of left heart ventricular hypertrophy.The initial sistolic and diastolic blood preassurres were 23,0±1,50 kPa and 14,2±kPa respectively.40 patients were without clinical signs of left heart failureand they were divided into two gro ups.Group I (20 patients) received calcium antagonist (Nifedipin R 2x20 mg).Group II(20 patients) was treated by diuretics amiloride (10 mg) and methychlothiazide (5 mg)co mbined in one tablet daily.Other 40 patients (Group III) were with clinical signs of left heart failure and they received diuretics furosemid (20 mg) and ACEinhibitor cilazapril (2,5 mg daily).All patients were submited to lung function tests(spirometry,flow-volume curve) toge ther with clinical examination,before and after 7-day treatment.
RESULTS: Our results showed that avera ge systolic and diastolic blood preassure after therapy were reduced to normale range both in all three groups patients.However,the lung function tests showed significant average increase in VC (p<0,02) and in FEV1 (p<0,01) after therapy only in group II and in group III(in VC p<0,001 and in FEV1 p<0,002).The therapy by Calcium antagonist is not followed by such effect on lung volumes.
CONCLUSION: It is concluded that essential hypertension with left ventricular hypertrophy with and without clinical signs of left heart failure is accompanied by fluid retention in the lungs which can be detected by spirometry before and after diuretic therapy.
CLINICAL IMPLICATIONS: We could recommend combining antihypertensive drugs with diuretics in treatment of hypertensive patients with and without clinical signs of left heart failure becouse they had positive effect on lung function.
DISCLOSURE: Ljiljana Corkovic, None.