PURPOSE: Very few paper about arterial stiffness in COPD patients are available. Several arguments are in favor of arterial wall alteration, especially artery distensibility. The purpose of this study is to assess peripheral arterial vascularisation and its consequences on physical exercise capacity in COPD patients.
METHODS: 26 COPD patients of similar age with severe air flow limitation (age 66 ± 5 [SD] yr; FEV1: 35% ± 5% predicted) and 14 healthy subjects (age 65 ± 5 [SD] yr) were studied. All subjects were free of cardiovascular disease, systemic blood hypertension and dyslipidemia. The purpose of this study was to compare systemic blood pressure, ankle-brachial index (ABI) and pulse wave velocity, used as indexes of the arterial mechanical properties in patients with sever COPD with their exercise capacity assessed using incremental exhausted exercises.
RESULTS: In the four arterial segments studied (carotid to femoral; carotid to radial; carotid to ankle and femoral to ankle), the PWV were higher and ABI significantly lower in COPD patients than in control group. Furthermore, in COPD patients PWV was significantly associated with maximal oxygen uptake (VO2max.) and maximal workload.
CONCLUSION: Peripheral arterial circulation is impaired in COPD patients.A significant and negative correlation between arterial stiffness and exercise capacity exists in patients with COPD.
CLINICAL IMPLICATIONS: ABI should be commonly used to detect arterial disease in this population.Arterial stiffness have to be assess in COPD patients before a rehabiliatation program.
DISCLOSURE: Olivier Castagna, None.