PURPOSE: Respiratory tract infections (RTIs) in children continue being the most frequent cause of morbidity. Concurrent diseases are usually in mind, but sometimes physicians forget to look for and treat linked allergies.
METHODS: As part of Data base record of Clinical Experience Attributable to oral form of Ampicillin/Sulbactam in children with RTIs (ECASEN) in various Venezuelan cities, we prospectively studied 234 pediatric patients (46% male; 3,79±3,54 y/o) with RTIs. The entities analyzed included: Otitis Media, Tonsillitis, Sinusitis, and Pneumonia. Global symptoms (GSyS) and signs (GSiS) severity were assessed at initial visit and at the end of therapy. GSyS was between 0: absent and 10: very bothering. GSiS was: 0-absent, 1-Mild, 2-Moderate, 3-Severe, and 4-very severe. Allergic diseases assessed were: Rhinitis (AR), Asthma (AS), and Dermatitis (AD).
RESULTS: Of the 234 patients analyzed, 53% had AR, 15% AS, and AD was present in 0.6%. The most common associated entity was sinusitis (32%), followed by otitis (17%). GSyS was higher (7.21 ± 1.16 points) for patients with AR than for any other allergic disorder. GSiS was also higher for AR at starting (2.35 ± 0.56 points). Although, both differences were not statistically significant (p>0.001). Efficacy of antimicrobial therapy in this setting is showed bellow:.
CONCLUSION: Allergic Disorders must be assessed in pediatric patients with RTIs and the severity of the clinical presentation may be related to the presence of them. Allergic disorder may not interfere with clinical response to antimicrobial therapy.
CLINICAL IMPLICATIONS: This experience in the real life setting shows that Allergic Disorders must be assessed in the majority of patients with RTIs and It must be kept in mind that they may not interfere with clinical response of RTI to antimicrobial therapy.
DISCLOSURE: Gemzel Hernandez, Employee Pfizer Venezuela.