PURPOSE: To investigate the role of co-stimulatory molecules CD134, CD134L and chemotatic factor RANTES in the pathogenesis of systemic lupus erythematosus (SLE) accompany lung injury.
METHODS: 6 male lupus-prone BXSB mice model and 6 syngeneic normal C57BL/6 male mice were included in this study. Real time fluorescence-quantitative polymerase chain reaction (RT-FQ PCR) was used to detect the mRNA expression of CD134, CD134L and RANTES in lung cells.
RESULTS: The mRNA expressions of CD134, CD134L and RANTES from lung cells in SLE model group were significantly higher than those from control groups (p<0.05). There was a positive correlation between CD134L mRNA expression and RANTES mRNA expression in model lung cells (r =0.793, P<0.05).
CONCLUSION: The abnormal expression of CD134, CD134L mRNA was well evidenced in the lung of lupus-prone BXSB mice.
CLINICAL IMPLICATIONS: Strong expression of RANTES mRNA was likely mediated by the activation of CD134/CD134L signal pathway, which may play an important role in the autoimmunity and pathogenesis of lung injury.
DISCLOSURE: Yanbin Zhou, None.