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RELATIONSHIP BETWEEN ACTIVATION OF CD134-CD134L AND THE SYNTHESIS OF RANTES IN LUNG CELLS OF LUPUS-PRONE BXSB MICE FREE TO VIEW

Yanbin Zhou, MD, PhD*; You-ji Li, MD; Canmao Xie, MD, PhD; Bin Hu, MD; Yubiao Guo, MD, PhD
Author and Funding Information

Department of Pulmonary & Critical Care Medicine, the First Affiliated Hospital, Guangzhou, Peoples Rep of China



Chest. 2006;130(4_MeetingAbstracts):228S-d-229S. doi:10.1378/chest.130.4_MeetingAbstracts.228S-d
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Abstract

PURPOSE: To investigate the role of co-stimulatory molecules CD134, CD134L and chemotatic factor RANTES in the pathogenesis of systemic lupus erythematosus (SLE) accompany lung injury.

METHODS: 6 male lupus-prone BXSB mice model and 6 syngeneic normal C57BL/6 male mice were included in this study. Real time fluorescence-quantitative polymerase chain reaction (RT-FQ PCR) was used to detect the mRNA expression of CD134, CD134L and RANTES in lung cells.

RESULTS: The mRNA expressions of CD134, CD134L and RANTES from lung cells in SLE model group were significantly higher than those from control groups (p<0.05). There was a positive correlation between CD134L mRNA expression and RANTES mRNA expression in model lung cells (r =0.793, P<0.05).

CONCLUSION: The abnormal expression of CD134, CD134L mRNA was well evidenced in the lung of lupus-prone BXSB mice.

CLINICAL IMPLICATIONS: Strong expression of RANTES mRNA was likely mediated by the activation of CD134/CD134L signal pathway, which may play an important role in the autoimmunity and pathogenesis of lung injury.

DISCLOSURE: Yanbin Zhou, None.


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