PURPOSE: To evaluate the cardiac function in patients with cystic (non-perfused) and cylindrical (perfused) bronchiectasis with emphasis on pulmonary artery pressure and to correlate the findings with the pulmonary function tests and C-T scan score.
METHODS: Ninety four patients, 65 (69%) females with mean age (± SD) 53.4 ± 17.7 years with the diagnosis of bronchiectasis proven by chest CT scan were recruited from out-patient clinic between July 2004 to June 2005. Echocardiography and pulmonary function tests were performed to all patients.
RESULTS: Left ventricular dysfunction (LVEF < 45%) was observed in 4% and right ventricular dysfuncion was observed in 10%. The prevalence of pulmonary hypertension (PAP > 35 mm Hg) was 43.9% in cystic vs 19.2% in cylindrical bronchiectasis(p-value <0.04). The right ventricular dimension was significantly higher in cystic disease (p-value 0.02), where as there was no statistical difference between left ventricular and right ventricular stroke volume among the two groups. Pulmonary pressure was negatively correlated with PO2, DLCO%, and FEV1 (p-value <0.0001) and positively was correlated with PCO2 (p-value <0.001), R2 = 0.21. Pulmonary hypertension was correlated with C-T scan score (p-value < 0.03), R2 = 0.05.
CONCLUSION: Left ventricular function was preserved in patients with bronchiectasis. Pulmonary hypertension was more prevalent in cystic disease and was correlated with deteriorated pulmonary function and high C-T scan sore.
CLINICAL IMPLICATIONS: Close follow up of patients with cystic bronchiectasis is warranted as early surgical intervention may avert further haemodynamic deterioration.
DISCLOSURE: Abdulaziz Alzeer, None.