PURPOSE: Mitral valve prolapse (MVP) is a common valvular abnormality. An association between MVP and low body mass index (BMI) has been proposed. The goal of this study was to evaluate association between MVP with low BMI using two independent large databases. For comparison, we evaluated association between bicuspid aortic valve (BAV) with low BMI.
METHODS: We retrospectively analyzed 1,742 echocardiograms that were performed as a part of a cardiac screening of teenage athletes in Southern California. and 24,265 echocardiograms performed at our institution between 1984 and 1998 for various clinical indications. Using uni- and multivariate analysis, we evaluated associations between MVP and BAV with BMI.
RESULTS: The first database included a total of 12,926 (53%) female and 11,339 (47%) male patients. The second database included a total of 1,172 male (67%) and 570 female (33%) high school athletes. MVP was independently associated with BMI in addition to mitral regurgitation in both data bases and tricuspid regurgitation in the larger database using uni- and multivariate analysis (BMI < 30) occurred in 78 of 13,874, 0.6% vs 7 of 3,236 0.2%, in the echo data base, p=0.03, OR= 2.4 CI: 1.1-5.2, BMI < 20 occurred in 7 of 354, 2% vs 6 of 944, 0.6% in the athletic data base, p= 0.03, OR=3.2 CI: 1.05-9.5). BAV did not have any association with low or high BMIs.
CONCLUSION: In our two independent databases, MVP was independently associated with low BMI in addition to mitral and tricuspid regurgitaton.
CLINICAL IMPLICATIONS: The cause of this association remains unknown but warrants further investigation.
DISCLOSURE: Mohammad-Reza Movahed, None.