PURPOSE: Mitral annulus calcification (MAC) is a common finding on echocardiographic examination. The goal of this study was to evaluate associations between MAC and cardiac abnormalities using a large echocardiographic database.
METHODS: We retrospectively reviewed 24,380 echocardiograms performed at our institution for clinical reason between 1984 and 1998 for this study using uni and multi variate analysis.
RESULTS: Mac was present in 1,494 (6.1%) subjects. Univariately, MAC was associated with age, gender, mitral, tricuspid and aortic regurgitation (MR, TR, AR), aortic stenosis (AS), abnormal early over late mitral flow reversal (reversed E/A ratio), dilated aortic rote, left atrial (LA) enlargement, body mass index (BMI) and LVH. Using multivariate analysis, age, LVH, MR, TR, AS, LA enlargement and reversed E/A ratio were independently associated with MAC. Mean age (68 with MAC and 50 years old without MAC, OR: 1.059, CI 1.054-1.062, p<0.0001), MAC in 11.7 % with MR vs. 4.3% without MR (OR: 2.0, CI 1.6-2.6, p<0.0001), MAC in 13.9% with TR vs. 4.5% without TR (OR: 3.8, CI 2.9-4.8, p<0.0001), MAC in 10.6% with LVH vs. 4.2% without LVH (OR: 1.9, CI 1.5-2.4, p<0.0001), MAC in 14.8% with AS vs. 5.5% without AS (OR: 1.4, CI 1.08-1.9, p=0.01) and MAC in 8.2% with LA enlargement vs. 4.8% without LA enlargement, OR: 1.3, CI 1.06-1.7, p=0.02).
CONCLUSION: In our study of a large number of patients undergoing echocardiography, MAC independently correlated with advanced age, MR, TR, AS, diastolic mitral flow reversal, left atrial enlargement and LVH.
CLINICAL IMPLICATIONS: Our finding suggests that the presence of MAC in not a benign condition.
DISCLOSURE: Mohammad-Reza Movahed, None.