0
Abstract: Poster Presentations |

SERUM VITAMIN C LEVEL IN PATIENTS WITH ACUTE PNEUMONIA AND IN COPD PATIENTS BEFORE AND AFTER THERAPY FREE TO VIEW

Ljiljana Corkovic, PhD*; Dragana Begovic, PhD; Tatjana Milosevic; Vladana Miloskovic, PhD; Momira Obradovic; Svetlana Jelic, PhD; Ratko Garovic; Tereza Maksimovic, PhD
Author and Funding Information

KBC Dr Dragisa Misovic, Belgrade, Serbia and Montenegro



Chest. 2006;130(4_MeetingAbstracts):184S. doi:10.1378/chest.130.4_MeetingAbstracts.184S-b
Text Size: A A A
Published online

Abstract

PURPOSE: The aim of the study was to compare the values of serum ascorbate concentration and laboratory indicators of inflammation in three groups of patients.

METHODS: Study included 60 patients divided in three groups. Group I: 20 patients with acute pneumonia, Group II: 20 patients with COPD in stable state and Group III: 20 patients with exacerbation of COPD. All patients were nonsmokers. Diagnosis was established by clinical, roentgenographic, laboratory (blood leukocyte count, ESR, fibrinogen) and lung function examinations (VC, FEV1, and ratio 100. FEV1/VC were determined).

RESULTS: Serum vitamin C concentrations were significantly decreased in group I and in group III patients before therapy, compared to patients after therapy (p<0,01). Laboratory indicators of inflammation are markedly increased in group I and in group III patients before therapy, compared to patients after therapy (p<0, 01). Also we observed negative correlation between vitamin C level and laboratory indicators of inflammation before and after therapy in group I and in group III patients. In group II patient’s serum vitamin C values before and after therapy were normal.

CONCLUSION: It is concluded that serum vitamin C is significantly decreased, and laboratory indicators of inflammation are markedly increased in patients with acute pneumonia and in patients with exacerbation of COPD before therapy, compared to patients after therapy. There was negative correlation between vitamin C level and laboratory indicators of inflammation before and after therapy in patients with acute pneumonia and in patients withexacerbation of COPD.

CLINICAL IMPLICATIONS: Vitamin C as an antioxidant is markedly decrease in inflammatory diseases (acute pneumonia and COPD during exacerbation). Elevation of vitamin C in serum is a good prognostic parameter for evaluation of diseases.

DISCLOSURE: Ljiljana Corkovic, None.

Wednesday, October 25, 2006

12:30 PM - 2:00 PM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543