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Abstract: Poster Presentations |

RETROSPECTIVE ANALYSIS OF COPD EXACERBATIONS IN PATIENTS TREATED WITH ALPHA1-PROTEINASE INHIBITOR AUGMENTATION THERAPY FREE TO VIEW

Val Romberg, BS; Alphonse Hubsch, DVM*
Author and Funding Information

ZLB Behring, Bern, Switzerland



Chest. 2006;130(4_MeetingAbstracts):184S. doi:10.1378/chest.130.4_MeetingAbstracts.184S-a
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Abstract

PURPOSE: To investigate the incidence of pulmonary exacerbations of chronic obstructive pulmonary disease (COPD) in patients with alpha1-proteinase inhibitor (A1-PI) deficiency receiving augmentation therapy with the products Zemaira® (ZLB Behring, Philadelphia, USA) [Z(A1-PI)] and Prolastin® (Talecris Biotherapeutics Inc., North Carolina, USA) [P(A1-PI)].

METHODS: This was a retrospective analysis of COPD exacerbations in a double-blind, controlled clinical study. A total of 44 patients with A1-PI deficiency were randomized to receive Z(A1-PI) 60 mg/kg or P(A1-PI) 60 mg/kg once weekly for 10 weeks. The following adverse events reported by investigators and in patient diaries were considered to be exacerbations of COPD: bronchitis, pneumonia, COPD exacerbation, lower respiratory tract infection, and asthma exacerbation. In addition, patients were required to meet the following American Thoracic Society criteria for pulmonary exacerbations: (a) two of the three primary diagnostic criteria, or (b) one primary and one supporting criterion.

RESULTS: Six out of 30 patients (20%) in the Z(A1-PI) group had a total of 7 exacerbations of COPD, compared with 9 of the 14 patients (64%) in the P(A1-PI) group, who had 11 exacerbations.

CONCLUSION: In this small study, the incidence of COPD exacerbations was less in patients receiving Z(A1-PI) compared with P(A1-PI). This finding should be investigated further in a larger trial.

CLINICAL IMPLICATIONS: Z(A1-PI) as augmentation therapy may result in fewer COPD exacerbations.

DISCLOSURE: Alphonse Hubsch, Employee VR and AH are employees of ZLB Behring.

Wednesday, October 25, 2006

12:30 PM - 2:00 PM


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