PURPOSE: To determine whether exercise-based interventions combined with a smoking cessation programme are more effective than a smoking cessation programme alone.
METHODS: 68 smokers were enrolled in the study. They received either nicotine replacement therapy (NRT) or NRT together with training (TG) randomly for 3 months.The primary endpoint was smoking cessation. Additionally, we measured forced expiratory volume (FEV1), exhaled carbon monoxide (CO), urine Cotinine and performed Saint George Respiratory Questionnaire (SGRQ) and Fagerstroem index.
RESULTS: In all patients, we achieved a significant cigarette cessation rate (44 out of 68 = 64%; P<0.001), a reduction in number of cigarettes (-21±10; P<0.001), proven by reduction in exhaled CO (-19±16; P<0.001), an improvement in functional parameters (FEV1=4%, VC=4%); P<0.05 and an improvement in Saint George Respiratory Questionnaire (SGRQ) of -34%; P<0.001.Within both groups, NRT had an efficacy of 52%, those with TG quit smoking in even 80%; P=0.019. Additionally, there were results with a comparable trend regarding cigarette reduction (NRT= -69%, TG= -85%; P=0.07), exhaled CO (NRT: -14.2 vs. TG: -26.96; P=0.07) and urine Cotinine levels (701.4 vs. 308.1; P=0.039).
CONCLUSION: Exercise training together with nicotine replacement therapy is feasible and aids smoking cessation.
CLINICAL IMPLICATIONS: Exercise training is an effective therapy without side effects and aids smoking cessation.
DISCLOSURE: Ralf Zwick, None.