PURPOSE: Sarcoidosis is a multisystem disorder, the range of symptoms and natural history varies tremendously. The relationship between quality of life, frequently reported symptoms and objective evaluations (PFT's, 6 min walk test) has not yet been studied.Purpose: To identify association(s) between Health Related Quality of Life scores with patients' objective clinical data. Using a cross sectional study to examine the correlation of frequently reported subjective symptoms (quality of life domains) with the 6 minute walk test and PFT's.
METHODS: A cross-sectional study was conducted at the Wayne State University. Patients were recruited from outpatient pulmonary clinics. They were given a Sarcoidosis Specific Health Questionnaire (SHQ) and a Short Form Survey (SF-36), which evaluated their Health Related Quality of Life (HRQL). These data were correlated with PFT's and 6 min walk test, after controlling for demographic variables and clinical parameters.
RESULTS: The most frequently reported symptoms with the largest impact on the patients were dyspnea (2.85), arthralgia (2.92), cough (3.07), and lack of energy (4.10) [lower the scale larger the impact]. FEV1% correlated well with dyspnea score as well as with the severity of cough. Similarly, DLCo correlated well with dyspnea score, and cough. Six minute walk test had a good predictive value on fatigue or lack of energy. However, none of the tests showed good correlation with joint pain.
CONCLUSION: Dyspnea is the most important symptom of the QOL domain of sarcoidosis patients. FEV1% and the DLCo% correlate well with dyspnea score and severity of cough. Patients' lack of energy reflects well on six minute walk test.
CLINICAL IMPLICATIONS: When evaluating sarcoidosis patients, it is recommended to focus on QOL domains, particularly, dyspnea, (arthralgia), cough and fatigue or lack of energy. Also, objective assessments are indicated (PFT's and six minute walk test) when these symptoms are encountered. QOL may be an early marker of disease activity and it may also influence the physicians desire to treat sarcoidosis early.
DISCLOSURE: Swapna Parikh, None.