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COMPARISON OF DEPTH OF SEDATION MEASURED BY PSA 4000 AND RICHMOND AGITATION-SEDATION SCALE (RASS) FREE TO VIEW

Curtis N. Sessler, MD*; Marin Kollef, MD; Anne Hamilton, RN; Mary Jo Grap, PhD; Deborah Jefferson, RN
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Virginia Commonwealth University, Richmond, VA


Chest


Chest. 2005;128(4_MeetingAbstracts):151S-b-152S. doi:10.1378/chest.128.3.1101
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Abstract

PURPOSE:  To investigate the relationship between electroencephalogram (EEG)-based Patient State Index (PSI) (a computed EEG variable using the PSA 4000 device (Physiometrix)) with the sedation or agitation level subjectively measured by Richmond Agitation-Sedation Scale (RASS) score in intubated and mechanically ventilated medical ICU patients.

METHODS:  After obtaining informed consent, PSI was measured continuously for up to 8hrs. RASS testing was performed at 2 hr intervals. PSI readings, obtained 5 minutes before, and immediately prior to RASS testing were documented for correlation with RASS (Pearson Correlation Coefficient). The distribution of PSI values for three clinically relevant RASS categories: A. 0 to +2 (alert, restless, or agitated); B. -1 to -3 (drowsy, light sedation, moderate sedation); C. -4 and -5 (deep sedation, unarousable) was also determined (ANOVA).

RESULTS:  Patients (n=20; 40% male; age 52 +17 years; APACHE II 27.5 + 6.5) underwent RASS testing on 78 occasions. Mean (+SD) RASS was -2.86 + 2.08, range = -5 to +2. PSI 5 minutes before RASS (66.1+19.8, range 13 to 99) and PSI immediately prior to RASS (66.7+20.1, range 12 to 99) were similar, and both correlated highly with RASS (r = 0.539, p < .0001, and r = 0.562, p < .0001, respectively). ANOVA revealed significant differences in PSI scores among clinical RASS categories at both time periods (both: n=78; p<0.0001). PSI values (mean, 95% confidence interval) are displayed for RASS categories in the Table.

CONCLUSION:  The significant associations between PSI and RASS support the validity of the PSA 4000 as a tool to monitor the level of sedation in the ICU.

CLINICAL IMPLICATIONS:  Additional research in larger populations and relevant subgroups, including further investigation of PSA 4000 as a clinical tool for sedation management, will further define its role in intensive care.

PSI immediately prior to RASS

RASS CategorynMean PSI95% Confidence IntervalsA (alert/agitated)1382.373.1 / 91.6B (mild-moderate sedation)2673.968.9 / 78.8C (deep sedation)3956.850.1 / 63.5

DISCLOSURE:  Curtis Sessler, Grant monies (from industry related sources) Physiometrix, Baxter.

Monday, October 31, 2005

2:30 PM - 4:00 PM


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