In terms of safety, pneumothorax after cryoablation can be sufficiently managed by course observation, by chest tube insertion, or, if persistent, by medical pleurodesis. However, in single-lung patients, delayed pneumothorax may have serious consequences if access to medical facilities is limited. We have previously reported that the incidence of delayed pneumothorax after cryoablation occurred in 30 of 193 patients (16%), mostly at 3 days after cryoablation still during admission. However, the incidence could occur as late as 20 days after cryoablation, and eight of these patients were readmitted after being discharged. Therefore, if the incidence of pulmonary toxicities after SRT is actually as low as generally reported (≤ grade 2, 5% ∼10%), we agree that SRT should be offered as a primary treatment option even in single-lung patients.