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Abstract: Poster Presentations |

RELAPSE AT 5 YEARS IN INDIAN REVISED NATIONAL TUBERCULOSIS CONTROL PROGRAMME CAT I DOTS REGIMEN FREE TO VIEW

Mukesh K. Tailor, MBBS*
Author and Funding Information

J.L.N. Medical College, Ajmer, India


Chest


Chest. 2005;128(4_MeetingAbstracts):404S. doi:10.1378/chest.128.4_MeetingAbstracts.404S
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Abstract

PURPOSE:  To see the relapse rate and point of relapse in cat-I DOTS treated patients after 5 years of chemotherapy under Indian Revised National Control Programme.

METHODS:  128 patients of Pulmonary-tuberculosis registered under cat-I DOTS, between Oct-1999 and March-2000. Out of 128 cases, 22 defaulted, 14 died, 5 failure and 2 transferred-out during treatment were excluded from analysis. Of remaining 85 cured cases, only 53 were analyzed because 32 could not be traced due to various reasons. Out of these 53, only 41 were alive at the time of assessment and 12 were found dead. Of the 53 patients, 12 were irregular during treatment. 7 alive-cases and 5 dead-cases were re-registered in DOTS cat-II (documented relapses). Verbal autopsy was carried out in all dead-cases and was conclusive that they all died because of symptomatic PTB.

RESULTS:  19 (35.85%) patients relapsed during 5 years post treatment period. Of these 6 (31.6%) relapsed within 6 months of completion of DOTS, 4(21%) between 6 to 18 months, 3(15.8%) between 19 to 36 months, 3 (15.8%) between 37 to 48 months and rest 3 during last 1 year of follow-up.

CONCLUSION:  Relapse rate following 5 years of cat-I treatment was very high (35.85%) and needs further studies to confirm these findings at large, because this has a significant bearing on eventual success of RNTCP in India.

CLINICAL IMPLICATIONS:  Relapse rate following 5 years of cat-I treatment was very high (35.85%) and needs further studies to confirm these findings at large, because this has a significant bearing on eventual success of RNTCP in India. We hypothesize high initial drug resistance prevalent in community, teething problem of 1st year of implementation and occasional defaults during DOTS possibly responsible for this high relapse rate.

DISCLOSURE:  Mukesh Tailor, Product/procedure/technique that is considered research and is not yet approved for any purpose.

12:30 PM - 2:00 PM


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