Recent literature implicate free radicals in physiologic/pathophysiologic processes and in wide spectrum of diseases.Tuberculosis is an ancient disease but has stayed in modern times. Mycobacteria are intracellular pathogens who grow and replicate in the host macrophages. In an attempt to kill mycobacteria, host cells namely-macrophages, neutrophills and monocytes generate huge amounts of reactive oxygen species, which also contribute to inflammatory injury to host tissues. Many studies are not avialable where oxidative stress and antioxidants have been studied in pulmonary tuberculosis (PTB). So present study was undertaken.
In 50 patients of PTB and 30 normal controls,malonyldialdehyde(MDA)as marker of oxidative stressand glutathione(GSM),Vit.C,superoxide dismutase(SOD)fot antioxidants status were studied.MDA,GSH,Vit. C and SOD were estimated by methods of Stocks and Dormandy(1971),Beutler et al (1963),varley (2004) and Marklund and Marklund (1974) respectively.Patients of PTB were classified according to radiological extant,sputum grading and cavity status.
Levels of MDA,GSM,Vit.C &SOD and there statistical significance is as given in table below there was significant correlation between radiological extent,sputum grading and cavity status of PTB and the levels of MDA, GSM,Vit. C and SOD.
There is oxidative stress and decreased antioxidants activity in patients of PTB which correlate with radiological extent,Sputum grading and cavity status.
Antioxidants can have role in patients of PTB for prevention and treatment of infammatory damage.
InvestigationStudy Group Mean ± SDControl Group Mean ± SDStat. Signi.MDA706.24 ± 158.68538.32 ± 147.72HSGSH31.59 ± 5.8236.16 ± 6.55HSVit. C0.68 ± 0.111.14 ± 0.22HSSOD18.83 ± 5.1024.04 ± 6.87HS
Jai Kishan, None.