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Abstract: Poster Presentations |

NOSOCOMIAL PNEUMONIA AND ANTIBIOTIC RESISTANCE FREE TO VIEW

Prashant S. Borade, MD*; Daniel K. Lee, MD
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Department of Respiratory Medicine, Ipswich Hospital, Ipswich, Suffolk, England, United Kingdom


Chest


Chest. 2005;128(4_MeetingAbstracts):374S. doi:10.1378/chest.128.4_MeetingAbstracts.374S
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Abstract

PURPOSE:  The emergence of antibiotic resistant pathogens poses a significant threat to patients with nosocomial pneumonia. It is therefore important to evaluate the relationship between hospital-acquired pathogens and antibiotic resistance.

METHODS:  A prospective study was conducted in 100 consecutive patients with hospital-acquired infections admitted to the intensive care unit of which 46% had clinical, laboratory, and radiological evidence of nosocomial pneumonia.

RESULTS:  Isolated pathogens consisted of Klebsiella spp. (29%), Pseudomonas spp. (16%), Acinetobacter spp. (13%), Staphylococcus aureus (11%), Escherichia coli (10%), Enterobacter spp. (9%), methicillin-resistant S. aureus (2%), and Candida spp. (9%). Details of antibiotic resistance are shown in Table 1. Mortality was 33% in patients with nosocomial pneumonia.

CONCLUSION:  Antibiotic resistance in hospital-acquired pathogens is significant.

CLINICAL IMPLICATIONS:  Patients with nosocomial pneumonia remain at risk from antibiotic resistant pathogens. Table 1—

Antibiotic Resistance in Hospital-acquired Pathogens.

Klebsiella spp.Pseudomonas spp.Acinetobacter spp.S. aureusAmikacin40%39%32%Cefazolin55%Cefoperazone71%Cefotaxime60%Ceftazidime46%46%36%Ceftriaxone48%79%45%Ciprofloxacin68%79%73%70%Cloxacillin60%Co-amoxiclav76%15%Piperacillin25%

DISCLOSURE:  Prashant Borade, None.

Wednesday, November 2, 2005

12:30 PM - 2:00 PM


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