The emergence of antibiotic resistant pathogens poses a significant threat to patients with nosocomial pneumonia. It is therefore important to evaluate the relationship between hospital-acquired pathogens and antibiotic resistance.
A prospective study was conducted in 100 consecutive patients with hospital-acquired infections admitted to the intensive care unit of which 46% had clinical, laboratory, and radiological evidence of nosocomial pneumonia.
Isolated pathogens consisted of Klebsiella spp. (29%), Pseudomonas spp. (16%), Acinetobacter spp. (13%), Staphylococcus aureus (11%), Escherichia coli (10%), Enterobacter spp. (9%), methicillin-resistant S. aureus (2%), and Candida spp. (9%). Details of antibiotic resistance are shown in Table 1. Mortality was 33% in patients with nosocomial pneumonia.
Antibiotic resistance in hospital-acquired pathogens is significant.
Patients with nosocomial pneumonia remain at risk from antibiotic resistant pathogens.
Antibiotic Resistance in Hospital-acquired Pathogens.Klebsiella spp.Pseudomonas spp.Acinetobacter spp.S. aureusAmikacin40%39%32%Cefazolin55%Cefoperazone71%Cefotaxime60%Ceftazidime46%46%36%Ceftriaxone48%79%45%Ciprofloxacin68%79%73%70%Cloxacillin60%Co-amoxiclav76%15%Piperacillin25%
Prashant Borade, None.