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Abstract: Poster Presentations |

RESPONSE OF PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION THAT DO NOT QUALIFY FOR TREATMENT WITH BOSENTAN TO TREATMENT WITH BOSENTAN FREE TO VIEW

Zoheir Bshouty, MD*
Author and Funding Information

University of Manitoba, Winnipeg, MB, Canada


Chest


Chest. 2005;128(4_MeetingAbstracts):367S. doi:10.1378/chest.128.4_MeetingAbstracts.367S
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Abstract

PURPOSE:  To asses the response of patients with underlying pulmonary arterial hypertension who do not qualify for treatment with bosentan to treatment with bosentan.

METHODS:  Fifteen patients (8 females and 7 males) with underlying pulmonary arterial hypertension who did not qualify for treatment with bosentan [3 with chronic thromboembolic disease (CTED), 2 with congenital and valvular disease (CVD), 3 with interstitial lung disease and severe fibrosis (ILD), and 7 with connective tissue disease and severe fibrosis (CTD+FIB)] where treated with bosentan. Bosentan was started at 62.5 mg PO BID and increased to 125 mg PO BID after 4 weeks. One patient with CTED was started on dual therapy with bosentan and sildenafil. Primary end points where 6-minute walk distance and NYHA functional class. Patients were assessed at baseline, 3 and 6 months.

RESULTS:  The overall 6-minute walk distance at baseline, 3 and 6 months (Mean±SE, meters) were 262.2±36.76, 357.4±38.60, and 366.3±44.92 respectively. Individual as well as group data (CTED, CVD, ILD, CTD+FIB) are shown in Figure 1. Overall NYHA class dropped from an average of 3 to 2.2 both at 3 and 6 months. All patients tolerated the treatment well. Two patients required a reduction in dose down to 62.5 mg PO BID.

CONCLUSION:  Patients with underlying pulmonary arterial hypertension that do not qualify for treatment with endothelin receptor antagonists may still benefit from treatment.

CLINICAL IMPLICATIONS:  More RCT are needed to assess the response to treatment in wider groups of patients with underlying pulmonary arterial hypertension.

DISCLOSURE:  Zoheir Bshouty, None.

Wednesday, November 2, 2005

12:30 PM - 2:00 PM


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