Residual pleural thickening is common complication of tuberculous pleurisy and sometimes in parapneumonic effusion. The aim of this study was assess the expression of MMP-1 and –9 and TGF-β, and then compared with amount of pleural fluid at the first time of detection and the end of follow-up.
Patients with newly diagnosis of pleural fluid was enrolled from June 2004 to January 2005. MMP-1, MMP-9 and TGF-β were determined by ELISA in plasma and pleural fluid. The amount of pleural fluid and pleural thickening were measured on the simple chest PA films.
The study included 39 patients with pleural effusion. Twenty-three was tuberculous, 7 parapneumonic effusion, 7 malignant effusion, and 2 transudates. The patients with malignant effusion(mean age 62±15 years) was more older than of tuberculos(40±18)(p=0.028). MMP-1 concentrations of parapneumonic effusion(9.6±8.5 pg/mL) was significantly higher than other pleural fluid(tuberculous 3.9±2.3, p=0.012; malignant 2.7±1.7, p=0.016, transudate 1.8±0.2, p=0.094). MMP-9 of parapneumonic effusion(383.6±410.0 ng/mL) was also significantly higher than other pleural fluid(tuberculous 74.0±68.7, p=0.002; malignant 62.1±61.0, p=0.007, transudate 40.0±42.4, p=0.058). In tuberculous effusion, the absortion of pleural fluid or thickening was significantly increased in accordance with lower concentration of MMP-1(p=0.011).In parapneumonic effusion, higher concentration of MMP-1, the amount of pleural fluid at the fist detection was significantly larger(p=0.014), but there was no correlation with absortion of pleural fluid or thickening. There was no correlation between TGF-β and pleural fluid or thickening.
Inconclusion, elevated MMP-1 and –9 expression was found in parapneumonic pleural effusion. The concentration of MMP-1 was correlated with amount or absortion in several exudative pleural effusion.
MMP-1 could be implicated in the resolution of pleural fluid or residual pleural thickening in tuberculous pleurisy and in the production of pleural fluid in parapneumonic effusion.
An Chang Hyeok, None.