Abstract: Poster Presentations |


An Chang Hyeok, MD*; Kim Yu Jin, MD; Kyung Sun Young, MD; Lee Sang Pyo, MD; Park Jeong Woong, MD; Jeong Seong Hwan, MD
Author and Funding Information

Gachon Medical School Gil Medical Center, Incheon, South Korea


Chest. 2005;128(4_MeetingAbstracts):360S. doi:10.1378/chest.128.4_MeetingAbstracts.360S-a
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PURPOSE:  Residual pleural thickening is common complication of tuberculous pleurisy and sometimes in parapneumonic effusion. The aim of this study was assess the expression of MMP-1 and –9 and TGF-β, and then compared with amount of pleural fluid at the first time of detection and the end of follow-up.

METHODS:  Patients with newly diagnosis of pleural fluid was enrolled from June 2004 to January 2005. MMP-1, MMP-9 and TGF-β were determined by ELISA in plasma and pleural fluid. The amount of pleural fluid and pleural thickening were measured on the simple chest PA films.

RESULTS:  The study included 39 patients with pleural effusion. Twenty-three was tuberculous, 7 parapneumonic effusion, 7 malignant effusion, and 2 transudates. The patients with malignant effusion(mean age 62±15 years) was more older than of tuberculos(40±18)(p=0.028). MMP-1 concentrations of parapneumonic effusion(9.6±8.5 pg/mL) was significantly higher than other pleural fluid(tuberculous 3.9±2.3, p=0.012; malignant 2.7±1.7, p=0.016, transudate 1.8±0.2, p=0.094). MMP-9 of parapneumonic effusion(383.6±410.0 ng/mL) was also significantly higher than other pleural fluid(tuberculous 74.0±68.7, p=0.002; malignant 62.1±61.0, p=0.007, transudate 40.0±42.4, p=0.058). In tuberculous effusion, the absortion of pleural fluid or thickening was significantly increased in accordance with lower concentration of MMP-1(p=0.011).In parapneumonic effusion, higher concentration of MMP-1, the amount of pleural fluid at the fist detection was significantly larger(p=0.014), but there was no correlation with absortion of pleural fluid or thickening. There was no correlation between TGF-β and pleural fluid or thickening.

CONCLUSION:  Inconclusion, elevated MMP-1 and –9 expression was found in parapneumonic pleural effusion. The concentration of MMP-1 was correlated with amount or absortion in several exudative pleural effusion.

CLINICAL IMPLICATIONS:  MMP-1 could be implicated in the resolution of pleural fluid or residual pleural thickening in tuberculous pleurisy and in the production of pleural fluid in parapneumonic effusion.

DISCLOSURE:  An Chang Hyeok, None.

Wednesday, November 2, 2005

12:30 PM - 2:00 PM




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