0
Abstract: Poster Presentations |

SIGNIFICANT IMPROVEMENT IN SPIROMETRY AFTER STEM CELL TRANSPLANTATION IN ONE DUCHENNE MUSCULAR DYSTROPHY PATIENT FREE TO VIEW

Zhiping Li, RRT; Yubiao Guo, MD*; Xiaoli Yao, MD; Cheng Zhang, MD; Canmao Xie, MD
Author and Funding Information

Department of Pulmonary & Critical Care Medicine, the First Affiliated Hospital, Guangzhou, Peoples Rep of China


Chest


Chest. 2005;128(4_MeetingAbstracts):356S. doi:10.1378/chest.128.4_MeetingAbstracts.356S-a
Text Size: A A A
Published online

Abstract

PURPOSE:  To describe the pattern of lung function abnormality and to investigate the changes in spirometry before and after autologus hematopoietic stem cell transplantation in one duchenne muscular dystrophy (DMD) patient.

METHODS:  Lung function was measured by maximum expiratory flow-volume loops and whole body plethysmography in one 14-yr old DMD patient before and three months after stem cell transplantation.

RESULTS:  Lung function test was characterized by restrictive pattern manifested by lung volume reduction and increased FEV1/FVC due to muscular weakness. Before stem cell transplantation, the FVC, FEV1 and MVV were 1.4L, 1.4L and 59.5L respectively. 3 months after stem cell transplantation, the patient’s FVC, FEV1 and MVV were significantly increased to 2.12L, 2.12L and 118.0L respectively.

CONCLUSION:  Although genetically modified myoblast transplantation remains controversial for DMD, a significant change in spirometry was found in this DMD patient after stem cell transplantation.

CLINICAL IMPLICATIONS:  Spirometric measurement provides a simple and useful means of assessing disease progression in DMD patients and should be considered when stem cell transplantation is planning.Furthermore, since DMD characterized by gradually developing muscular weakness, pulmonary physical rehabilitation should focus on the training of respiratory accessory muscles.

DISCLOSURE:  Yubiao Guo, None.

Wednesday, November 2, 2005

12:30 PM - 2:00 PM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543