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Abstract: Poster Presentations |

ASSESSING REGIONAL LUNG FUNCTION IN SINGLE LUNG TRANSPLANT (SLT) RECIPIENTS USING A NEW VIBRATION RESPONSE IMAGING (VRI*) TECHNOLOGY FREE TO VIEW

Mordechai R. Kramer, MD*; Yael Raviv, MD; Ruth Hardoff, MD; Merav Gat, MA; Igal Kushnir, MD
Author and Funding Information

Rabin Medical Center, Petach Tikva, Israel


Chest


Chest. 2005;128(4_MeetingAbstracts):340S. doi:10.1378/chest.128.4_MeetingAbstracts.340S
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Abstract

PURPOSE:  Background: In a well functioning graft following SLT most of the ventilation (V) and perfusion (Q) shifts to the transplanted (Tx) side. A routing V/Q scan is performed periodically to asses the graft function. Chest auscultation usually discloses a difference between the Tx and non-Tx lungs, however no quantitative nor regional assessment can be done by the physical examination.VRI is a new system that records the vibrations produced by airflow and converts the signals to a dynamic image of the lung. The vibration energy throughout the breathing cycle can be quantified for any lung region, by integrating the energy over 40 acoustic sensors .Objective: To evaluate the correlation between regional vibration (VRI) energy and regional lung function as assessed by radionuclide V/Q scan.

METHODS:  We examined 28 stable patients (12 F/16 M; age 58.6+9.8 yrs: FEV1 58.3+15%) who underwent SLT (18 Left lung, 10 Right lung). Patients underwent V/Q scans and VRI testing. For each mode, the chest was divided into 6 areas, 3 at each side, and the corresponding regional signals (fraction of the total radioactivity vs. fraction of the VRI energy units) were integrated and compared.

RESULTS:  The regional VRI evaluations were found to be highly correlated with the V/Q results (R=0.92, p<0.001) (see figure). The images of all subjects shared similar features with hyperdynamic vibration of the transplanted lung as compared to the native side with excellent correlation to the V/Q.

CONCLUSION:  VRI has excellent corellation to lung V/Q scan in stable patients following SLT.

CLINICAL IMPLICATIONS:  These preliminary findings suggest that VRI may provide a simple, radiation-free novel tool to assess qualitatively and quantitatively lung function in lung transplanted patients and to monitor the patient during the post-operative period for acute or chronic rejection.* www.deepbreeze.com.

DISCLOSURE:  Mordechai Kramer, None.

Wednesday, November 2, 2005

12:30 PM - 2:00 PM


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