Background: In a well functioning graft following SLT most of the ventilation (V) and perfusion (Q) shifts to the transplanted (Tx) side. A routing V/Q scan is performed periodically to asses the graft function. Chest auscultation usually discloses a difference between the Tx and non-Tx lungs, however no quantitative nor regional assessment can be done by the physical examination.VRI is a new system that records the vibrations produced by airflow and converts the signals to a dynamic image of the lung. The vibration energy throughout the breathing cycle can be quantified for any lung region, by integrating the energy over 40 acoustic sensors .Objective: To evaluate the correlation between regional vibration (VRI) energy and regional lung function as assessed by radionuclide V/Q scan.
We examined 28 stable patients (12 F/16 M; age 58.6+9.8 yrs: FEV1 58.3+15%) who underwent SLT (18 Left lung, 10 Right lung). Patients underwent V/Q scans and VRI testing. For each mode, the chest was divided into 6 areas, 3 at each side, and the corresponding regional signals (fraction of the total radioactivity vs. fraction of the VRI energy units) were integrated and compared.
The regional VRI evaluations were found to be highly correlated with the V/Q results (R=0.92, p<0.001) (see figure). The images of all subjects shared similar features with hyperdynamic vibration of the transplanted lung as compared to the native side with excellent correlation to the V/Q.
VRI has excellent corellation to lung V/Q scan in stable patients following SLT.
These preliminary findings suggest that VRI may provide a simple, radiation-free novel tool to assess qualitatively and quantitatively lung function in lung transplanted patients and to monitor the patient during the post-operative period for acute or chronic rejection.* www.deepbreeze.com.
Mordechai Kramer, None.