The favourable survival benefits of surgical resection for early stage non small cell primary bronchial cancer is well recognized. The value of lung resection for advanced lung cancer with locoregional spread or extrapulmonary disease is less clear. The aim of the study is to determine the influence of disease stage on survival after resection for lung cancer, compare the annual death hazards for different stages of the disease and determine if the prognostic significance of disease stage changes with time.
The study cosisted of a retrospective interrogation of the prospectively collected information in the Albany Medical College Cancer Registry Database on 292 patients who underwent pulmonary resection for lung cancer over a 10 year period. Survival analysis was performed using the Kaplan-Meir method. Hazard Function calculations were performed to determine the annual risk of dying in the different stage groups.
Operative mortality was 2.4%. Overall survival was 42.8%. Survival was significantly different for the different stages of the disease (P=0.001). Estimation of the instantaneous risk of dying revealed annual death hazards to be highest during the 5 year period for stage 3 disease. Death hazards subsequently declined for all stages. By the 5th year of followup, the difference in death hazards between the stages had nearly dissapeared.
The study suggests that the prognostic significance of disease stage on early survival is diminished in later follow up.
The chance of potential cure increases with longer follow up for patients with lung cancer with no evidence of systemic spread, who have undergone locoregional control by surgical resection.
Adebambo Kadri, None.