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Abstract: Poster Presentations |

PRIMARY LUNG CANCERS DISCOVERED AS SOLITARY PULMONARY NODULE: REVIEW OF 209 CASES FREE TO VIEW

Pier Luigi Filosso, MD*; Davide Turello, MD; Giovanni Donati, MD; Fausto Pernazza, MD; Ottavio Rena, MD; Caterina Casadio, MD; Enrico Ruffini, MD; Alberto Oliaro, MD
Author and Funding Information

University of Torino, Department of Thoracic Surgery, Torino, Italy


Chest


Chest. 2005;128(4_MeetingAbstracts):339S. doi:10.1378/chest.128.4_MeetingAbstracts.339S-a
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Abstract

PURPOSE:  to assess the prognostic factors and outcome of primary lung cancers (PLCs) discovered as solitary pulmonary nodules (SPNs).

METHODS:  between 1999 and 2003 314 patients (223 male-71%-, mean age 64 years-range 21-81 years-) underwent surgical resection of a SPN. Of these 209 (66%) were PLCs, 56 (17%) lung metastases and 49 benign lesions.

RESULTS:  One hundred and ten (75%) out of 209 PLCs were adenocarcinomas, 58 (18.7%) squamous cell carcinomas, 12 bronchioloalveolar carcinomas, 8 large cell carcinomas and 12 bronchial carcinoids. Nine patients had mixed tumors. Twenty-six (12.6%) were less than 1 cm. in size; 100 (47.5%) between 1.1 and 2 cm, and 83 (39.9%) between 2.1 and 3 cm. One hundred thirty-seven (65.7%) were N0; 25(11.9%) were N1 and N2, respectively; in 22 (10.5%) lymphadenectomy was not performed. Three and five year overall survival rates were 70% and 52%, respectively. The following prognostic variables resulted statistically significant at multivariate analysis: the tumor histology (p=0.0005), the tumor size (p=0.007), the presence of lymphnodal metastases (p=0.00001), the visceral pleura invasion (p=0.0002) and the extent of resection (anatomic vs. limited resection) (p=0.004).

CONCLUSION:  this is a surgical series with a high PLCs percentage (66%), the majority of which were at early stage. An early diagnosis and surgical treatment represent the treatment of choice, especially in high risk patients, providing a good survival.

CLINICAL IMPLICATIONS:  in high risk patients PLC should be considered in occasionally discovered SPN. Early diagnosis and possible surgical treatment are mandatory.

DISCLOSURE:  Pier Luigi Filosso, None.

Wednesday, November 2, 2005

12:30 PM - 2:00 PM


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