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Abstract: Poster Presentations |

EFFECT OF LUNG RESECTION ON EXERCISE CAPACITY AND ON CO DIFFUSING CAPACITY DURING EXERCISE FREE TO VIEW

Jeng-Shing Wang, MD*
Author and Funding Information

E-Da Hospital & I-Shou University, Kaohsiung, Taiwan ROC


Chest


Chest. 2005;128(4_MeetingAbstracts):337S. doi:10.1378/chest.128.4_MeetingAbstracts.337S
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Abstract

PURPOSE:  To evaluate the effect of lung resection on lung function and exercise capacity values including DLCO during exercise, and to determine whether postoperative lung function including exercise capacity and DLCO during exercise could be predicted from the preoperative lung function and the number of functional segments resected.

METHODS:  Design: Prospective study.Setting: Clinical pulmonary function laboratory in a university teaching hospital.Patients: Twenty-eight patients undergoing lung resection at Vancouver General Hospital from October 1998 to May 1999, were studied preoperatively and one year postoperatively. Interventions: We determined FEV1 and FVC, and maximal oxygen uptake (VO2max/kg) and maximal workload (Wmax) achieved during incremental exercise testing. We used the 3-equation modification of the single breath DLCO technique, method, to determine DLCO at rest and during steady state exercise at 70% of Wmax, and the increase in DLCO from rest to exercise (70%-R)DLCO. We calculated the predicted postoperative (ppo) values for all the above parameters using the preoperative test data and the extent of functioning bronchopulmonary segments resected, and compared results with the actual one year postoperative results.

RESULTS:  Following lung resection, there was a significant reduction in FEV1, FVC, and DLCO with decreases of 12%, 13%, and 22% of predicted respectively. There were also significant decreases in VO2max/kg of 2.1 ml/min/kg ( 8% of predicted VO2max) and in Wmax of 12watts (7% of predicted Wmax). However, (70%-R)DLCO, did not significantly decrease after lobectomy but decreased after pneumonectomy. The calculated ppo values significantly underestimated postoperative values in pneumonectomy, but were acceptable for lobectomy.

CONCLUSION:  Predicted postoperative results calculated by estimating the functional contribution of the resected segments, are comparable with those obtained using ventilation perfusion lung scanning, and significantly underestimate postoperative lung function after pneumonectomy, but are acceptable for lobectomy.

CLINICAL IMPLICATIONS:  Exercise tests may be better indicators of functional capacity after lung resection than measurements of FEV1 and FVC or DLCO at rest.

DISCLOSURE:  Jeng-Shing Wang, None.

Wednesday, November 2, 2005

12:30 PM - 2:00 PM


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