The aim of our study was to determine whether the size of a primary NSCLC predicts the presence of brain metastases.
We retrospectively reviewed the size of lung mass by CT scan of the chest in 35 patients (16 males, 19 females, age range 41-95 yrs; mean age 67.4yrs) who were diagnosed with NSCLC during the past two years whose CT scans of the brain were negative for brain metastases. We then compared it with the size of the lung mass in CT scan of the chest in 35 patients (16 males, 19 females, age range 41-91 yrs; mean age 65.7 Yrs) who were also diagnosed with NSCLC but had CT scans of the brain that showed brain metastases.
The size of lung mass in patients without brain metastases was smaller (mean 3.311±1.668cm; 95%CI= 2.738-3.884) than in those with brain metastases (mean 4.866±2.612cm; 95%CI=3.969-5.763). At a cut-off of 3.9cm (determined by ROC curve analysis), the odds ratio of brain metastases was 13.96 (P<0.0001).
There is direct correlation between the size of the lung mass and brain metastases in NSCLC.
Lung mass size ≥ 3.9cm in NSCLC predicts the presence of brain metastases.
Lung Mass Size (cm)MetastasesNo Metastases≥3.9266<3.9929
M.M. Ismail, None.