To evaluate the impact of smoking history and smoking cessation after diagnosis on performance status and survival in patients with lung cancer.
Retrospective analysis of patients with NSCLC seen at our pulmonary function laboratuary between Jan’01 and Nov‘01. Clinical characteristics, smoking history, comorbidities, survival, performance status, and pulmonary function tests were reviewed. We estimated the association between smoking status after diagnosis and survival and performance change from baseline to 6 months and 12 months.
We studied 206 patients: 93 (45%) were smokers, 15 (7%) were nonsmokers, and 98 (48%) were former smokers (>1year). There was no significant association between smoking history at diagnosis and change in performance status (ZUBROD) and survival. Of the 93 smokers, 46 quit and 47 continued smoking after diagnosis. Stage, age, gender, and comorbidities were similar between these two groups. There was no significant association between smoking status after diagnosis and patients’ survival. However, those who quit smoking maintained a better performance status at 6 and 12 months (p=0.006 and p=0.008) than those who continued smoking.
Smoking history before and after diagnosis of lung cancer did not affect survival, but patients who quit smoking maintained a better performance status than those who continued smoking.
Smoking cessation after diagnosis of lung cancer has a beneficial effect on performance status but not on survival.
Sevin Baser, None.