0
Abstract: Poster Presentations |

CORRELATION BETWEEN SURVIVIN EXPRESSION AND PROGNOSIS IN NON-SMALL CELL LUNG CANCER FREE TO VIEW

Sükran Atikcan, MD*; Ebru Ünsal, MD; Funda Demirag, MD; Deniz Köksal, MD; Aydin Yilmaz, MD
Author and Funding Information

Atatürk Chest Diseases and Chest Surgery Education Hospital, Ankara, Turkey


Chest


Chest. 2005;128(4_MeetingAbstracts):332S. doi:10.1378/chest.128.4_MeetingAbstracts.332S
Text Size: A A A
Published online

Abstract

PURPOSE:  Survivin is a recently identified protein as an inhibitor of apoptosis, which supresses programmed cell death and regulates cell division. In this study, we investigated the prognostic significance of both nuclear and cytoplasmic survivin expression in non small cell lung cancer (NSCLC) and examined the association with clinicopathological parameters.

METHODS:  The study comprised 58 male patients diagnosed NSCLC with a mean age of 57.29±8.82 years; range 40-76 years. Patients underwent lobectomy (36%) or pneumonectomy (64%) with hilar and mediastinal lymph node sampling. Paraffin embedded tumor sections were retrieved for evaluation of nuclear and cytoplasmic staining of survivin. Clinicopathological data, stage and survival of patients were all determined.

RESULTS:  Cytoplasmic staining was found significantly increased in squamous cell carcinoma (p=0.003), whereas there was no association between nuclear staining and histopathological type (p=0.837). Also, both nuclear and cytoplasmic staining did not show any association with tumor stage (p>0.05). In univariate analysis there was significant correlation between nuclear survivin and short survival (p=0.0002). In multivariate survival analysis using Cox regression, only nuclear staining of survivin was determined as an independent prognostic factor (p=0.001).

CONCLUSION:  Localisation of survivin expression might have an important regulatory mechanism in carcinogenesis and tumor progression. Nuclear survivin expression in tumor tissues might predict the prognosis in NSCLC, whereas cytoplasmic survivin has no prognostic significance.

CLINICAL IMPLICATIONS:  Survivin expression in tumor tissues can be used as a prognostic factor in lung cancer and can be helpful in the evaluation of disease.

DISCLOSURE:  Sükran Atikcan, None.

Wednesday, November 2, 2005

12:30 PM - 2:00 PM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543