The present study aimed to acquire more information about the role of platelet derived-endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP), vascular endothelial growth factor (VEGF) and cathepsin-D (Cath-D) as angiogenic factors in the pathogenesis and progression of lung cancer.
Patients: The study included histopathologically confirmed lung biopsies of 37 patients with bronchogenic carcinoma, 12 patients with benign chest diseases and 12 non -inflammatory non malignant biopsies as control. Bronchogenic carcinoma cases were classified into squamous cell carcinoma (14), adenocarcinoma (10), large cell carcinoma (6) and small cell lung carcinoma (7).
The present study showed a significant increase in the tissue levels of studied bioindices in patients with lung cancer in comparison to other groups, with significant higher levels in patients with inoperable cancer, advanced stages, bulky tumors and with lymph node metastasis. Also, Significant higher tissue levels of VEGF and Cath-D were also demonstrated in lung adenocarcinoma cases.
The present study indicates the importance of the studied bioindices as angiogenic factors in pathogenesis and progression of lung cancer.
Therefore the development of new therapeutic agents with an anti- angiogenic action may be of great importance in the management of patients with lung cancer.
Clinical Characteristics of the Studied Patients and Controls.VariableControls (n=12)Patients with benign chest disease (n=12)Lung cancer patients (n=37)Number121237Gender (m/f)8/45/727/10Age (mean± SD) Range45.6±11.6 22-7045.0±12.7 20-6261.2±7.52 42-72Smoking Non smokers Ex-smokers Smokers8 (80%) 2 (20%) 0 (0%)7 (58.3%) 2 (16.7%) 3 (25%)8 (21.6%) 11(29.7%) 18 (48.7%)Final diagnosis Free COPD IPF Bronchiectasis Old pulmonary TB12 (100%) -----5 (41.8%) 3 (25.0%) 2 (16.6%) 2 (16.6%)-----
Aliae Mohamed, None.