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Abstract: Poster Presentations |

SOLUBLE HER-2/NEU OVEREXPRESSION IN PATIENTS WITH LUNG CANCER FREE TO VIEW

Mohammad A. Ghayumi, MD*; Mehrnoosh Doroodchi, MD; Kambiz Aghasadeghi, MD
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Shiraz University of Medical Sciences, Shiraz, Iran


Chest


Chest. 2005;128(4_MeetingAbstracts):330S. doi:10.1378/chest.128.4_MeetingAbstracts.330S-c
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Abstract

PURPOSE:  The Her-2/neu oncogene encode a growth factor receptor, P185. Overexpression of this protein is thought to confer a growth advantage to tumors and has been associated with an adverse outcome in Non Small Cell Lung Cancer.

METHODS:  This study is a case-control, cross sectional study to evaluate the clinical usefulness of soluble Her-2/neu as a marker in the diagnosis of lung cancer. Level of soluble Her-2/neu in 43 lung cancer patients and 42 age/sex matched controls, measured by an enzyme immunoassay method.

RESULTS:  More than 93% of patients aged more than 55 years and 83% of lung cancer patients were smoker. Mean serum level of soluble Her-2/neu in cancer patients was 6.07±10.37 ngr/ml which was significantly higher than that of control (P < 0.05). Cigarette smoking has no effect on the level of soluble Her-2/neu. A cut off level of 6.1 ngr/ml revealed a high specificity (95%) for diagnosis of lung cancer, with very low sensitivity (14%). Conclusion: The results of this study show the higher level of soluble Her-2/neu in the sera of lung cancer patients with high specificity and low sensitivity for a cut off level of 6.1 ngr/ml.

CONCLUSION:  The results of this study show the higher level of soluble Her-2/neu in the sera of lung cancer patients with high specificity and low sensitivity for a cut off level of 6.1 ngr/ml.

DISCLOSURE:  Mohammad Ghayumi, None.

Wednesday, November 2, 2005

12:30 PM - 2:00 PM


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